Abstract: Objective:To assess the efficacy and safety of oncoplastic breast-conserving surgery (OBCS) in the treatment of early breast cancer. Methods: The clinicopathological data of breast cancer patients who were treated with OBCS ( 67cases) and standard breast-conserving surgery (SBCS; 117 cases) in Affiliated Cancer Hospital of Guangxi Medical University were retrospectively analyzed. Postop-erative complication, specimen weight, margins, and surgery re-excision rate between the two groups were compared. Results:Sero -ma ( 14. 9% versus 48. 7%,P<0. 001 ), hematoma ( 4. 5% versus 14. 5%,P=0. 035 ), and poor wound healing ( 3. 0% versus 11. 9%,P=0. 036 ) were more common in the SBCS group than in the OBCS group. The patient satisfaction in the OBCS group was statistically higher than in the SBCS group ( P<0. 05). Compared with standard surgery, oncoplastic techniques can be employed for significantly larger tumors (25. 04mm versus21. 14mm, P<0. 001 ). OBCS resulted in higher mean specimen weights (92. 24g versus 57. 44g, P<0. 001 ), wider clear nearest margins (12. 04mm versus9. 58mm, P<0. 001 ), and wider furthest margins ( 24. 16mm versus15. 24mm, P<0. 001 ). No statisti -cal increase was observed in further surgery re-excision of margins. Conclusion: OBCS is more successful than standard wide local exci -sion in treating larger tumors and obtaining wider radial margins. Oncoplastic approach showed no increase in postoperative complica -tion rate. The postoperative complication was excellent. OBCS is a safe and effective procedure for early breast cancer.