Abstract: Objective:To retrospectively analyze and summarize the clinical characteristics of15glioma cases that led to leptomenin -ges and spinal cord metastases in Department of Glioma, Beijing Shijitan Hospital, Capital Medical University since2011. Methods:A total of15cases were considered, including 5 patients with World Health Organization gradeⅡ, 6 patients with grade Ⅲ, and 4 pa-tients with grade Ⅳ. One patient had a tumor at the brain stem, two patients had tumors at the spinal cords, and the other patients had tumors at the hemispheres. One case received biopsy, 4 cases received subtotal resection, and 10cases received complete resec-tion. Results: Symptoms included low back pain, sensory and motor dysfunction, incontinence, and seizures. After the metastases spread to the cerebrospinal region, patients were treated with chemotherapy, whole spine radiotherapy, intrathecal chemotherapy, and target therapy. The median time of leptomeninges and spinal cord metastasis dissemination appearance was 10months (1. 5- 80 months) since surgery. The median overall survival time of the15patients was20months (9- 83months), and the median survival time was 6 months (2- 48months) after leptomeninges and spinal cord metastases. Conclusion: The prognosis of glioma patients with lepto -meninges and spinal cord metastases was poor, and a proportion of the patients who received appropriate treatment might have a better survival.