张连雪①②, 徐猛③, 杨本强①, 刘文源①, 林森①, 王子文②, 段阳①. 高低级别脑胶质瘤的MRS 代谢产物与Ki-67表达相关性研究*[J]. 中国肿瘤临床, 2016, 43(7): 281-284. DOI: 10.3969/j.issn.1000-8179.2016.07.024
引用本文: 张连雪①②, 徐猛③, 杨本强①, 刘文源①, 林森①, 王子文②, 段阳①. 高低级别脑胶质瘤的MRS 代谢产物与Ki-67表达相关性研究*[J]. 中国肿瘤临床, 2016, 43(7): 281-284. DOI: 10.3969/j.issn.1000-8179.2016.07.024
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Lianxue ZHANG1, 2, Meng XU3, Benqiang YANG1, Wenyuan LIU1, Sen LIN1, Ziwen WANG2. Correlation of Ki-67expression with MRS metabolism in low- and high-grade cerebral gliomas[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2016, 43(7): 281-284. DOI: 10.3969/j.issn.1000-8179.2016.07.024
Citation: Lianxue ZHANG1, 2, Meng XU3, Benqiang YANG1, Wenyuan LIU1, Sen LIN1, Ziwen WANG2. Correlation of Ki-67expression with MRS metabolism in low- and high-grade cerebral gliomas[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2016, 43(7): 281-284. DOI: 10.3969/j.issn.1000-8179.2016.07.024
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高低级别脑胶质瘤的MRS 代谢产物与Ki-67表达相关性研究*

Correlation of Ki-67expression with MRS metabolism in low- and high-grade cerebral gliomas

    摘要
  • 摘要: 目的：通过研究明确高低级别脑胶质瘤的磁共振波谱分析（magnetic resonance spectroscopy，MRS ）代谢产物与Ki-67表达的关系。方法：选取沈阳军区总医院2013年7 月至2015年7 月病理证实为胶质瘤的56例患者均行Ki-67和MRS 检查；分析Ki-67表达程度与瘤体Cho 值、NAA 值的关系。结果：35例低级别组脑胶质瘤（WHOⅠ～Ⅱ级）Ki-67的表达程度与瘤体Cho 值呈正相关（r s = 0.714，P < 0.05），与瘤体NAA 值呈负相关（r s =-0.708，P < 0.05）；21例高级别组脑胶质瘤（WHOⅢ～Ⅳ级）Ki-67的表达程度与瘤体Cho 值呈正相关（r s = 0.624，P < 0.05），Ki-67的表达程度与肿瘤实质NAA 值呈负相关（r s =-0.769，P < 0.05）。 结论：高低级别脑胶质瘤MRS 代谢产物与Ki-67表达相关。

     

    Abstract: objective: To investigate the relationship between magnetic resonance spectroscopy (MRS) metabolism and Ki- 67expres -sion in high- (HGG) and low-grade gliomas (LGG) by analyzing Ki- 67expression and HGG and LGG metabolites. Methods:We consid-ered 56pathologically confirmed glioma cases in our hospital. The Ki- 67expression and the MRS metabolism parameters in the tu-mors were analyzed simultaneously. Results:The tumor solid value of Cho was positively correlated with the Ki-67expression level (rs=0. 714 , P<0. 05). By contrast, the Ki- 67expression level was negatively correlated with the tumor solid value of NAA ( rs=− 0. 708 , P<0. 05) in 35cases of the LGG group. The tumor solid value of Cho was also positively correlated with the Ki-67expression level (rs=0. 624 , P<0. 05). By comparison, the Ki-67expression level was negatively correlated with the tumor solid value of NAA in the HGG group ( rs=−0. 769 , P<0. 05). Conclusion: The MRS metabolism was correlated with the Ki- 67expression in high- and low-grade gliomas.

     

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