转录因子Klfs 家族影响肝细胞癌发生发展的机制研究进展*

Mechanism of transcription factors KLFs in the occurrence and development of HCC

摘要: 肝细胞癌（hepatocellular carcinoma ，HCC ）是我国常见的恶性肿瘤之一，死亡率高，其发生与发展的具体分子机制尚不明确。Krüppel样因子家族（Klfs）是具有锌指结构的高度保守的转录因子家族，共包括17个家族成员。近年来，关于Klfs 与肝癌发病机制的研究不断深入，发现Klf2、Klf4、Klf5 等家族成员参与肝癌细胞的增殖、分化和浸润转移等过程。本文就Klfs 家族成员的功能以及在肝癌发生发展中的作用机制进行综述。

Abstract: Hepatocellular carcinoma (HCC) is one of the most lethal human cancers in China. The specific molecular mechanism of its occurrence and development is unclear. Krüppel-like factor family (KLF), which includes17members, is a highly conserved transcrip -tion factor family with zinc finger structure. The mechanism of KLFs and the pathogenesis of HCC have been studied in recent years. Re -search revealed that KLF 2, KLF 4, KLF 5, and other KLF family members could be involved in the progression of proliferation, differentia-tion, invasion, and metastasis of HCC. This review summarizes the function and the mechanism of transcription factors KLF in the oc -currence and development of HCC.