Abstract: The Sprouty protein can inhibit cell proliferation and induce apoptosis by specific interventions in the signaling pathways of tumor cells, such as receptor tyrosine kinase signaling pathway. The Sprouty protein, which is often associated with abnormal cell proliferation and transformation, is down-regulated in many tumors, stimulating the initiation and progression of tumors. The Sprouty protein exhibits potential for developing effective treatment against cancer. This paper reviews research progress on Sprouty protein in tumor.