Abstract: Objective: To compare efficacy of percutaneous vertebroplasty (PVP) with radiotherapy and radiotherapy alone for bone me-tastasis pain. Methods:A total of 247 bone metastasis patients with pain were analyzed. The radiotherapy group comprised 158 cases, whereas the combination group comprised89cases. We mainly observed the effect of pain treatment, behavioral states, and im -proved emotional condition. The side effects and complications were also investigated. Daily medicine consumption of background pain treatment was observed between the two groups. Analysis was done by SPSS 17. 0 statistical software. Numerical variables were analyzed using t test and comparisons between groups used chi-square test. Results:The VAS scores of radiotherapy group decreased from 8. 12± 1. 45to 3. 06± 1. 68after treatment ( P<0. 05), and combination group VAS scores from 8. 46± 1. 73to 2. 45± 1. 47(P<0. 05). The time to pain relief following PVP and radiotherapy were 1. 63± 0. 81and 8. 56± 2. 87days, respectively ( P<0. 001 ). The breakthrough pain frequency was 4. 56± 1. 98times/day, which decreased to 1. 57± 0. 98times/day after PVP ( P<0. 05). By contrast, the breakthrough pain frequency was 4. 73± 2. 24times/day before treatment, which decreased to 3. 56± 1. 56times/day after radiotherapy. No serious compli -cations were observed in the two groups. The depression and anxiety mood in the combination group improved after treatment. Daily medicine consumption in radiotherapy group increased after therapy. However, daily medicine consumption in combination group was reduced after therapy. Conclusion: PVP with radiotherapy can effectively relieve bone metastasis pain and improve patients' quality of life and it is worthy of promotion in clinical practice.