Abstract: STMN1 is a microtubule- destabilizing protein that regulates cell cycle by phosphorylation and dephosphorylation. It plays an important role in the proliferation and differentiation of cells, in addition to the tumorigenesis. This protein is highly expressed in a wide variety of human cancers, including leukemia and multiple types of solid tumors. The relationship between STMN1 and gastric cancer has recently been investigated. Studying STMN 1 in gastric cancer is important. A number of studies have suggested that overex -pression of STMN1 can affect the therapeutic response of docetaxel, an anti-microtubule drug. This review summarizes the role of ST -MN1 in gastric carcinogenesis, development, prognosis, and treatment. The relationship between STMN 1 and clinical pathology and its regulation pathways is also investigated.