刘薇, 熊文婕, 李姮, 刘慧敏, 李增军, 吕瑞, 邱录贵, 易树华. 惰性B 细胞非霍奇金淋巴瘤与肝炎病毒感染相关性分析[J]. 中国肿瘤临床, 2016, 43(11): 480-485. DOI: 10.3969/j.issn.1000-8179.2016.11.206
引用本文: 刘薇, 熊文婕, 李姮, 刘慧敏, 李增军, 吕瑞, 邱录贵, 易树华. 惰性B 细胞非霍奇金淋巴瘤与肝炎病毒感染相关性分析[J]. 中国肿瘤临床, 2016, 43(11): 480-485. DOI: 10.3969/j.issn.1000-8179.2016.11.206
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Wei LIU, Wenjie XIONG, Heng LI, Huimin LIU, Zengjun LI, Rui LV, Lugui QIU, Shuhua YI. Correlation analysis of indolent B-cell non-Hodgkin lymphoma and hepatitis virus[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2016, 43(11): 480-485. DOI: 10.3969/j.issn.1000-8179.2016.11.206
Citation: Wei LIU, Wenjie XIONG, Heng LI, Huimin LIU, Zengjun LI, Rui LV, Lugui QIU, Shuhua YI. Correlation analysis of indolent B-cell non-Hodgkin lymphoma and hepatitis virus[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2016, 43(11): 480-485. DOI: 10.3969/j.issn.1000-8179.2016.11.206
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惰性B 细胞非霍奇金淋巴瘤与肝炎病毒感染相关性分析

Correlation analysis of indolent B-cell non-Hodgkin lymphoma and hepatitis virus

    摘要
  • 摘要: 目的：分析惰性B 细胞非霍奇金淋巴瘤（B cell non-Hodgkin lymphoma，B-NHL）不同亚型患者乙型肝炎病毒（hepatitis B virus，HBV ）及丙型肝炎病毒（hepatitis C virus，HCV ）感染的情况，探讨惰性B-NHL不同亚型与肝炎病毒感染的相关性。方法：回顾性分析中国医学科学院血液病医院1994年1 月至2014年1 月收治的733 例初诊惰性B-NHL患者的肝炎病毒感染资料。与全国一般人群相对照，比较惰性B-NHL患者与全国一般人群肝炎病毒感染的差异。比较分析惰性B-NHL各亚型患者肝炎病毒感染的情况，并探讨其相关性。结果：733 例惰性B-NHL患者乙肝表面抗原（hepatitis B surface antigen ，HBs-Ag）阳性率为7.9% ，与全国一般人群比较，差异无统计学意义（7.9% vs . 7.2% ，P = 0.548）。 在惰性B-NHL中，脾边缘区淋巴瘤（splenic marginal zone lymphoma，SMZL）48例，HBs-Ag阳性率为18.8% ，明显高于全国一般人群（18.8% vs . 7.2% ，P = 0.002）、其他惰性B-NHL（18.8% vs . 7.2% ，P = 0.004）及其他边缘区淋巴瘤（marginal zone lymphoma ，MZL）患者（18.8% vs . 7.1%，P = 0.005）。惰性 B-NHL其他亚型患者 HBs-Ag阳性率比较全国一般人群，差异均无统计学意义（P > 0.05）。 在HBs-Ag阳性患者中，乙肝“大三阳”在惰性B-NHL不同亚型中无显著性差异，但乙肝“小三阳”在SMZL 组占16.7% ，明显高于其他惰性B-NHL组（16.7% vs . 4.7% ，P < 0.001）。 惰性B-NHL患者抗丙型肝炎病毒抗体（hepatitis C virus antibody，HCV-Ab）阳性率为1.9% ，较全国一般人群明显升高（1.9% vs . 0.4% ，P < 0.001）。 其中慢性淋巴细胞白血病（chronic lymphocytic leukemia ，CLL）、淋巴浆细胞性淋巴瘤/ 华氏巨球蛋白血症（lymphoplasmacytic lymphoma/waldenström macroglobulinemia ，LPL/WM）、SMZL、毛细胞白血病（hairy cell leukemia ，HCL ）、结内边缘区淋巴瘤（nodal marginal zone B-cell lymphoma，NMZL）组患者抗HCV-Ab 阳性率分别为2.2% 、2.5% 、4.2% 、3.0% 、3.7% 均较全国一般人群明显升高（均P <0.05）。 而慢性B 淋巴细胞增殖性疾病不能分类（B-cell lymphoproliferative disorders，unclassified ，B-LPD-U）、黏膜相关淋巴组织结外边缘区淋巴瘤（extranodal marginal zone B-cell lymphoma of mucosa-associated tissue lymphoma ，MALT）、B-幼淋巴细胞白血病（B-cell prolymphocytic leukaemia，B-PLL ）、滤泡性淋巴瘤（follicular lymphoma ，FL）组与全国一般人群比较，差异均无统计学意义（均P > 0.05）。 结论：SMZL 患者HBs-Ag阳性率明显高于全国一般人群及其他惰性B-NHL各亚型，提示HBV 感染与我国SMZL 的发生发展存在一定的相关性。

     

    Abstract: Objective:To differentiate hepatitis B virus (HBV) infection from hepatitis C virus (HCV) infection among different indolent B-cell non-Hodgkin lymphoma (B-NHL)subtypes. The correlation between indolent B-NHL and hepatitis viral infection was also investi-gated. Methods:A total of 733 indolent B-NHL patients from January 1994to January 2014with integrated clinical information were retrospectively investigated. We compared the hepatitis viral infection between the general population and indolent B- NHL patients. We analyzed the infection rate of hepatitis virus in the different indolent B-NHL subtypes and examined their correlations.Results:The HBs-Ag positive rate of the indolent B-NHL was7. 9%, which was not significantly different with that of the general population ( 7. 9% vs . 7. 2%,P=0. 548 ). Among the different indolent B-NHL subtypes, the 48splenic marginal zone lymphoma (SMZL) patients exhibited the highest HBs-Ag positive rate, which was significantly higher than those of the general population ( 18. 8% vs . 7. 2%, P=0. 002 ), other indo-lent B-NHL subtypes (18. 8% vs . 7. 2%,P=0. 004 ), and other marginal zone B cell lymphoma (MZL) patients (18. 8% vs . 7. 1%,P=0. 005 ). The HBs-Ag positive rates between other B-NHL subtypes and the general population were not significantly different. The coexpression of HBs-Ag, HBe-Ag, and anti-HBc-Ab exhibited no significant difference among the various B-NHL subtypes. However, the co-expres-sion of HBs-Ag, HBe-Ab, and anti-HBc-Ab was significantly higher in the SMZL group than the other B-NHL subtypes (16. 7% vs . 4. 7%, P< 0. 001 ).The positive rate of the anti-hepatitis C virus antibody (HCV-Ab) was 1. 9% in 733 indolent B-NHL patients, which was significant -ly higher than in the general population ( 1. 9% vs . 0. 4%, P<0. 001 ). The HCV-Ab positive rates in the chronic lymphocytic leukemia, lym - phoplasmacytic lymphoma/Waldenström macroglobulinemia, SMZL, hairy cell leukemia, nodal marginal zone B-cell lymphoma group were2. 2%, 2. 5%, 4. 2%, 3%, and 3. 7%, respectively. These values were significantly higher than those of the general population. Prevalence rates of HCV in B-cell lymphoproliferative disorders, unclassified, extranodal marginal zone B-cell lymphoma of mucosa-associat ed tissue lymphoma, B-cell prolymphocytic leukemia, and follicular lymphoma groups were not significantly different compared with the general population. Conclusion: Prevalence rate of HBV was higher in the SMZL group than other indolent B- NHL groups, which suggests that HBV infection may play an etiologic role in SMZL.

     

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