Abstract: Objective:To investigate the clinicopathological characteristics, treatments, and survival of patients with esophageal adeno -squamous carcinoma (EASC). Methods:A total of 494 patients with EASC were selected from the clinical information databases of 500 ,000 cases with esophageal and gastric cardiac carcinomas in the Henan Key Laboratory for Esophageal Cancer Research. Among the 494 EASC cases, 361 were males with an average age of61. 47± 8. 32years, and 133 were females with an average age of65. 56± 8. 06 years. SPSS 21. 0 software was applied to determine the statistical differences among the different groups. A life-table method was also used to calculate the five-year survival rate. A linear regression model was used to analyze the correlation of changes at different peri-ods. Results:The incidence of EASC in our database was 0. 196 % (494 /251707). EASC occurred predominantly in male patients (male: female= 2. 71:1. 00). The peak age was within 60- 69years in both males and females ( 39. 6% vs.40. 6%). Notably, the incidence of male patients showed a downward trend(R2=0. 063 ), whereas that of female patients showed an upward trend (R2=0. 004 ). The prevalence of EASC was obviously higher in low-incidence areas for esophageal cancer than in high-incidence areas (53. 1% vs . 46. 9%, P<0. 001 ). Ac -cording to the TNM staging criteria for esophageal cancer, phases II and III patients comprised the majority of cases, which accounted for 40. 8% (173 /424 ). The positive lymph node metastasis rate was 47. 0% (206 /438 ), and the number of positive lymph node metasta -ses ranged within 1- 2 (48. 5%,100 /206 ). In addition, preoperative biopsy was performed in 467 cases, and more than half of the patients ( 53. 96% ,252 /467 ) were diagnosed before the operation. Surgical resection was the predominant treatment method for EASC (88. 8%,419 /472 ). Only 1. 9% patients ( 9/472 ) underwent radiotherapy and chemotherapy. The five-year survival rate of male patients who were neither smoking nor drinking of alcohol was higher than that of male smokers (26. 5% vs . 12. 1%). In patients with stages Ⅰ, Ⅱ, and Ⅲ+ Ⅳcarcinomas with surgery as lone treatment, the three-year survival rates were 64. 7%,50. 9%, and 48. 5%, respectively. Correspondingly, these rates were 51. 7%, 47. 8%, and 33. 1% after adjuvant radiotherapy and chemotherapy. Conclusion: EASC is a rare type of esophageal malignant tumor. The preoperative biopsy pathological diagnosis has high misdiagnosis rate. Smoking and drinking of alcohol can influence the prognosis of patients. In EASC patients, lymph node metastasis easily occurs, and a simple surgery is better than other cancer treatments.