HOTAIR与肿瘤生物学行为的研究进展*

Research progress on HOTAIR in tumor biological behaviors

摘要: 长链非编码RNA（long noncoding RNA，lncRNA）是一类长度> 200 bp，无蛋白质编码产物，却广泛参与细胞的生理及病理学过程，特别是在肿瘤生物学行为方面。HOX转录反义RNA （HOX transcript antisense RNA，HOTAIR）全长2 158 bp，是功能研究最为深入的lncRNA 之一。HOTAIR 过表达可以沉默特定抑癌基因的表达并促进多种上皮系统来源恶性肿瘤，如乳腺癌、结直肠癌等的发生及转移，抑制肿瘤中HOTAIR 表达能有效抑制肿瘤细胞生长与侵袭能力。本文结合国内外文献报道，就HOTAIR 在肿瘤中的研究进展进行综述。

Abstract: Long non-coding RNA (lncRNA) is a cluster with over200 bp in length and has no protein-encoding product RNA, which is in -volved in cellular physiological or pathological process, especially in human oncogenesis. HOX transcript antisense RNA (HOTAIR), which is2158bp in length, is one of the most well-studied lncRNAs. Overexpression of HOTAIR is correlated with oncogenesis or me -tastasis in numerous epithelium original human cancers, including breast and colorectal cancers. Inhibiting HOTAIR expression could suppress cell growth and invasive ability of tumors. This review provides a brief summary of the latest progress in lncRNA-based can -cer research.