Abstract: KPNA2 is a member of the karyopherin family. Given its function in nucleocytoplasmic transport, KPNA 2 mediates the trans-location of various proteins and is involved in numerous cellular processes, such as cellular differentiation, proliferation and apoptosis, transcriptional regulation, immune response, and viral infection. Several studies have recently demonstrated that KPNA 2 is upregulat -ed in multiple malignancies. Its aberrant expression is often associated with adverse outcomes in affected patients, indicating that KP-NA2 plays a significant role in carcinogenesis and tumor progression. These findings are supported by previous studies, which reported that KPNA2 may have a functional role in the malignant transformation of cells. This study provides an overview of the research prog-ress in KPNA2 and its functional roles in multiple cancers.