徐龙①②, 张冠中②, 郑振东②, 谢晓冬②. 血清 CEA 及CA 153 连续且显著降低对晚期乳腺癌无影像学进展的判定价值[J]. 中国肿瘤临床, 2016, 43(19): 865-868. DOI: 10.3969/j.issn.1000-8179.2016.19.665
引用本文: 徐龙①②, 张冠中②, 郑振东②, 谢晓冬②. 血清 CEA 及CA 153 连续且显著降低对晚期乳腺癌无影像学进展的判定价值[J]. 中国肿瘤临床, 2016, 43(19): 865-868. DOI: 10.3969/j.issn.1000-8179.2016.19.665
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Long XU1, 2, Guanzhong ZHANG2, Zhendong ZHENG2. Predictive value of continuous and significant reduction of serum CEA and CA153 for non-imaging progression in patients with advanced breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2016, 43(19): 865-868. DOI: 10.3969/j.issn.1000-8179.2016.19.665
Citation: Long XU1, 2, Guanzhong ZHANG2, Zhendong ZHENG2. Predictive value of continuous and significant reduction of serum CEA and CA153 for non-imaging progression in patients with advanced breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2016, 43(19): 865-868. DOI: 10.3969/j.issn.1000-8179.2016.19.665
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血清 CEA 及CA 153 连续且显著降低对晚期乳腺癌无影像学进展的判定价值

Predictive value of continuous and significant reduction of serum CEA and CA153 for non-imaging progression in patients with advanced breast cancer

    摘要
  • 摘要: 目的：探讨晚期乳腺癌患者化疗后血清CEA 及CA153 连续且显著降低对无影像学进展的判定价值。方法：回顾性分析2011年1 月至2015年12月93例沈阳军区总医院住院化疗的晚期乳腺癌患者的病历资料，实施疗效评价188 次，有完整CEA 、CA153 数据的病例分别为105、139 例次，分析血清CEA 及CA153 连续且显著降低对于疾病无影像学进展的判定效度。结果：CEA连续降低且降低总幅度达10% 时，敏感度为54.1% ，特异度为95% ；CA153 连续降低且降低总幅度达40% 时，敏感度为19.1% ，特异度为96.6% 。结论：血清CEA 及CA153 连续降低分别达10% 与40% 以上时可作为晚期乳腺癌患者的疗效判定指标。

     

    Abstract: Objective:This study evaluates the relationship between carcino- embryonic antigen (CEA) and carbohydrate antigen 153 (CA 153 ) continuous and remarkable reduction after chemotherapy and no-imaging progression in patients with advanced breast can -cer. Methods:Medical records of 93patients who received chemotherapy in the Oncology Department of the General Hospital of Shenyang Military Command were included in the retrospective analysis. A total of 188 CEA and CA 153 serum data were collected from response evaluations that included 105 CEA cases and139 CA153 cases. Predictive validity of serum CEA and CA 153 was as -sessed for diagnosing no-imaging progression. Results:CEA was continuously reduced by 10%, with sensitivity of54. 1% and specificity of 95%. CA153 was continuously reduced by 40%, with sensitivity of19. 1% and specificity of 96. 6%. Conclusion: Serum CEA and CA 153 could be considered as response evaluation tools when they are continuously reduced by at least 10% and40%, respectively.

     

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