Abstract: Minimally invasive treatment has received increasing attention in the field of tumor therapy. Imaging-guided ablation (phys-ical or chemical) and 125I particle implantation have recently become first-line therapies for malignant tumors. A comparison with com-puted tomography, ultrasound, or digital subtraction angiography (DSA) illustrates that magnetic resonance imaging (MRI) shows ex-treme superiority in both intracranial tumor diagnosis and interventional therapy. Nevertheless, MRI also has a deficiency. This study aims to discuss the value of an MRI-guided minimally invasive treatment in glioma and its metastatic tumor.