Objective   This study investigates the clinical effect of body γ-knife combined with radiosensitizer and/or hyperthermia. for the recurrence of soft tissue sarcoma.

  Methods   Sixty-three patients with recurrent soft tissue sarcoma from January 2012 to March 2014 were treated by body γ-knife combined with radiosensitizer and/or hyperthermia. The patients were exposed to radiation dose levels of 4-5.5 Gy/fraction (10-13 fractions) with total doses of 44-55 Gy and 55%-70% isodose, including 95% PTV. The radiosensitizer, sodium glycodidazolum (CMNa), was administered to all patients at 1.00-1.50 g V.D qod at 5-6 fractions 0-3 h before body γ-knife treat-ment. Hyperthermia for 30 patients was delivered during the body γ-knife treatment with two fractions/week for a total of six frac-tions.

  Results   The total response rate was 77.7% three months after the treatment. The one and two year local control rates were 78.8% and 63.6%, respectively, while the survival rates of patients treated with body γ-knife with radiosensitizer at one and two years were 75.7% and 63.6%, respectively. The local control rates at one and two years were 83.6% and 70.0%, respectively, while the survival rates at one and two years for body γ-knife combined with radiosensitizer and hyperthermia treatments were 80.0% and 63.3%, respectively. Serious complications of radiotherapy were not observed.

  Conclusion   Body γ-knife combined with radiosensitizer and/or hyperthermia is effective for recurrent soft tissue sarcoma.