Abstract: Soft tissue tumors have specific morphologies. In many cases, differential diagnoses pose a challenge, and as such, immuno-histochemical and molecular methods are often needed. With the development of molecular genetics, the discovery of new diagnostic antibodies and genetic targets, and the emergence of further applications to clinical practice, clinically individualized and precision treatments have also been widely used. In the future, however, we must further investigate the molecular mechanisms of soft tissue tumors to improve their diagnosis and tr eatment.