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摘要: 早期诊断、精准治疗可以明显改善恶性肿瘤患者的预后。有研究发现肿瘤新生血管不仅在肿瘤的发生发展中起着极其关键的作用，也是肿瘤诊治的重要靶点。特定序列的多肽可以特异地靶向肿瘤新生血管内皮细胞上的特定分子。放射性核素标记这类小分子多肽所制备的分子探针在肿瘤诊治方面具有优势。本文将以我们的研究成果为主，阐述放射性核素标记小分子多肽RGD及RRL在靶向肿瘤新生血管的显像与治疗方面的应用研究进展。
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关键词:
- 肿瘤新生血管 /
- RGD肽 /
- 氨酰-甘氨酰-天冬氨酸 /
- αvβ3
Abstract: Early diagnosis and precision medicine generally show significant differences in the prognosis of patients with carcinoma. Angiogenesis not only plays a key role in tumor pathophysiology but also acts as an important drug target. Peptides with specific sequences can target specific molecules on the endothelial cellular membrane during tumor angiogenesis. Radionuclide-labeled molecular probes exhibit many advantages in oncotherapy. This article focuses on the progress of radionuclide-labeled RGD and RRL in radioimmunoimaging and radioimmunotherapy targeting tumor angiogenesis.-
Key words:
- tumor angiogenesis /
- RGD peptide /
- RRL /
- αvβ3
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