陈玉锦, 王海峰, 颜汝平, 柯昌兴, 丁明霞, 栾婷, 邹仁超, 王剑松. LASS2-3'-非翻译区rs8444 单核苷酸多态性与膀胱癌易感性的相关性研究[J]. 中国肿瘤临床, 2017, 44(3): 107-111. DOI: 10.3969/j.issn.1000-8179.2017.03.240
引用本文: 陈玉锦, 王海峰, 颜汝平, 柯昌兴, 丁明霞, 栾婷, 邹仁超, 王剑松. LASS2-3'-非翻译区rs8444 单核苷酸多态性与膀胱癌易感性的相关性研究[J]. 中国肿瘤临床, 2017, 44(3): 107-111. DOI: 10.3969/j.issn.1000-8179.2017.03.240
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CHEN Yujin, WANG Haifeng, YAN Ruping, KE Changxing, DING Mingxia, LUAN Ting, ZOU Renchao, WANG Jiansong. Analysis of the correlation between rs8444 polymorphisms located within LASS2- 3′-UTR and susceptibility of bladder cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 44(3): 107-111. DOI: 10.3969/j.issn.1000-8179.2017.03.240
Citation: CHEN Yujin, WANG Haifeng, YAN Ruping, KE Changxing, DING Mingxia, LUAN Ting, ZOU Renchao, WANG Jiansong. Analysis of the correlation between rs8444 polymorphisms located within LASS2- 3′-UTR and susceptibility of bladder cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 44(3): 107-111. DOI: 10.3969/j.issn.1000-8179.2017.03.240
shu

LASS2-3'-非翻译区rs8444 单核苷酸多态性与膀胱癌易感性的相关性研究

Analysis of the correlation between rs8444 polymorphisms located within LASS2- 3′-UTR and susceptibility of bladder cancer

    摘要
  • 摘要:
      目的  探讨人源性长寿保障基因2（Homo sapiens longevity assurance homologue 2，LASS2）-3'-非翻译区（UTR）单核苷酸多态性与中国云南地区膀胱癌人群之间的相关性。
      方法  选择2011年1月至2015年1月在昆明医科大学第二附属医院就诊且经病理学确诊的105例膀胱癌作为膀胱癌组、100例非膀胱癌作为对照组进行病例对照研究，对两组患者的膀胱组织进行基因扩增和测序，分析研究LASS2-3'-非翻译区单核苷酸多态性与膀胱癌之间的相关性。
      结果  在LASS2-3'-非翻译区仅发现1个单核苷酸多态性位点rs8444，经χ2检验和Logistic回归分析显示，膀胱癌组和对照组rs8444T/C等位基因频率及基因型分布差异具有统计学意义（χ2=10.267，P=0.006；χ2=10.634，P=0.001）。与携带T等位基因或TT基因型相比，携带C等位基因或CC基因型的个体发生膀胱癌的风险显著降低（OR=0.489，95%CI为0.309～0.772，P=0.002；OR=0.258，95%CI为0.081～0.827，P=0.023），但与膀胱癌的TNM分期、病理分级和有否转移无明显相关性（P>0.05）。
      结论  LASS2-3'-非翻译区rs8444C等位基因和CC基因型可降低膀胱癌的发病风险，但与膀胱癌的TNM分期、病理分级和转移情况无关。

     

    Abstract:
      Objective   To explore the correlation between single nucleotide polymorphisms (SNPs) in Homo sapiens longevity assurance homologue 2 (LASS2) gene 3′-untranslated regions (UTR) and susceptibility of bladder cancer among residents of Yunnan, China.
      Methods   A total of 105 bladder cancer patients (bladder cancer group) and 100 nonbladder cancer patients (control group) were selected. PCR method and sequence for LASS2-3′-UTR were performed to identify the SNPs correlated with bladder cancer. The relationships between the LASS2-3′- UTR polymorphisms and bladder cancer risk were analyzed.
      Results   An SNP (rs8444) was identified in LASS2-3′-UTR, and the T/C allele frequencies and genotype distributions of rs8444 largely differed between the bladder cancer and control groups (χ2=10.267, P=0.006; χ2=10.634, P=0.001). Individuals that carry the rs8444 C allele or CC genotype had a remarkably lower risk of bladder cancer compared with those that carry the T allele or TT genotype (OR=0.489, 95%CI: 0.309-0.772, P=0.002; OR= 0.258, 95%CI: 0.081-0.827, P=0.023). No significant correlations were observed between the T/C allele frequencies and genotype distributions of rs8444 and TNM stage, as well as histological grade and distant metastasis in bladder cancer (P>0.05).
      Conclusion   The rs8444 C allele or CC genotype located within LASS2-3′-UTR can lower the susceptibility of bladder cancer among the residents of Yunnan, China. However, it is not associated with the TNM stage, histological grade, and distant metastasis.

     

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