EHD2与E-cadherin 在肝细胞肝癌中的表达及其相关性

刘金霞; 瞿利帅; 陆翠华; 倪温慨; 倪润洲

doi:10.3969/j.issn.1000-8179.2017.03.329

EHD2与E-cadherin 在肝细胞肝癌中的表达及其相关性

Expression and correlation of EHD2 and E-cadherin in hepatocellular carcinoma

摘要

摘要:
目的研究EHD2、E-cadherin蛋白在肝细胞肝癌中的表达及两者相关性。
方法 Western blot法和免疫组织化学法检测肝细胞肝癌及对应的癌旁组织中EHD2与E-cadherin表达情况，分析两者的相关性及与患者临床病理学参数及预后的关系。
结果 EHD2、E-cadherin蛋白在肝癌组织中的表达明显低于癌旁组织，且两者的表达水平与肝癌的组织分化程度、静脉侵袭及淋巴结转移密切相关（P＜0.05），与年龄、性别、肿瘤大小等参数无相关性。EHD2、E-cadherin低表达与肝癌患者的不良预后显著相关（P＜0.05）。
结论 EHD2、E-cadherin蛋白表达与肝细胞肝癌的发生发展有关，两者的联合检测有助于肝细胞肝癌的诊断、恶性程度及预后的评估。

Abstract:
Objective To investigate the expression and correlation of EHD2 and E-cadherin in hepatocellular carcinoma (HCC).
Methods Western blot and immunohistochemistry were used to detect the expression of EHD2 and E-cadherin in HCC specimens and adjacent noncancerous tissues. The correlations of EHD2 and E-cadherin with the clinicopathological characteristics and prognosis of patients were further analyzed using Pearson χ² test and Kaplan-Meier method.
Results EHD2 expression, along with E-cadherin, was markedly reduced in HCC tissues than in adjacent noncancerous tissues. Moreover, EHD2 and E-cadherin expression were correlated with histological grade, microvascular invasion, and lymph node metastasis (P＜0.05). Kaplan-Meier survival analysis showed that HCC patients with decreased EHD2 and E-cadherin expression had shorter overall survival time than those with higher expression.
Conclusion The abnormal expression of EHD2 and E-cadherin possibly promote HCC. Detection of EHD2 and E-cadherin may be valuable for diagnosing HCC and evaluating malignancy extent and prognosis.

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