Objective   This study explored the clinical characteristics, imaging features, biological characteristics, treatment, and prognosis of solid-pseudopapillary tumor of the pancreas (SPT).

  Methods   We collected clinical data of 50 cases of SPT in Tianjin Medical University Cancer Istitute and Hospital from January 2011 to October 2016. We then retrospectively reviewed and analyzed clinical and pathological features of these patients. We conducted follow-up consultations and summarized data on patient characteristics, pathological features, diagnosis, treatment, and prognosis.

  Results   Among 50 SPT patients, mean age was 33.0±12.00 years, and maleto- female ratio was 1:5.25. Clinical presentation was mostly an abdominal placeholder diagnosed by physical examination, and tumor was usually located in the head or body and tail of the pancreas. All patients received surgery; procedures included pancreaticoduodenectomy, and distal pancreatectomy plus spleen resection. SPT was clearly diagnosed with postoperative histopathological examination. Hospital stay lasted for 13.9±5.16 days. All 50 cases were followed up, with consultation period lasting for 3-70 months. No recurrence or metastasis appeared in 49 cases, and perioperative death was not noted in our patients.

  Conclusion   SPT is a rare, potential low-grade malignant tumor, which mostly affects young females. There is no obvious specificity in the clinical manifestation and laboratory examination. Tumor marker levels are almost within normal range. Surgery for SPT provides good prognosis and long survival duration.