Abstract:
Objective To compare the efficacy between chemotherapy with granulocyte colony-stimulating factor (G-CSF) and chemotherapy with G-CSF and granulocyte-macrophage colony-stimulating factor (GM-CSF) for the mobilization of peripheral blood hematopoietic stem cells and hematological recovery post-transplantation in patients with malignant lymphoma.
Methods Autologous peripheral blood hematopoietic stem cell mobilization data of 61 malignant lymphoma patients who were treated with chemotherapy plus G-CSF or chemotherapy plus G-CSF and GM-CSF from May 2008 to October 2016 were included in this study. The mobilization efficacy and hematopoietic recovery were analyzed.
Results During mobilization, White blood cells (WBC) of all patients decreased to 1.0×109/L and platelets (PLT) dropped to 40×109/L. The successful mobilization rates of CD34+ cell are 52.5% in chemotherapy plus GCSF group and 90.5% in chemotherapy plus G-CSF+GM-CSF group (P=0.003). All patients successfully underwent hematopoietic reconstruction without transplantation-related mortality.
Conclusion Although chemotherapy with G-CSF + GM-CSF can significantly increase the effect of autologous peripheral blood hematopoietic stem cell mobilization, the reconstruction of hematopoietic function after transplantation and side reaction between the two groups are the same. Thus, chemotherapy with G-CSF+GM-CSF is not superior to chemotherapy with G-CSF in mobilizing autologous peripheral blood hematopoietic stem cells.