直肠癌术前放化疗完全缓解后的临床策略分析

李全营; 杜冰豫; 秦长江; 郭国校; 任学群

doi:10.3969/j.issn.1000-8179.2017.09.282

直肠癌术前放化疗完全缓解后的临床策略分析

Treatment strategy of complete response cases after neoadjuvant radiotherapy in rectal cancer

摘要

摘要:
目的探讨直肠癌经新辅助放化疗后获得完全缓解病例的处理办法。
方法回顾性分析河南大学淮河医院2010年1月至2014年8月收治的直肠癌术前进行新辅助放化疗的84例患者临床资料。
结果经过新辅助放化疗，33例（39.3%）患者获得临完全床缓解（clinical complete response，cCR）；经术后病理检查，6例患者获得病理完全缓解（pathological complete response，pCR），占cCR病例的18.2%（6/33），术后随访12~36个月均未出现肿瘤转移复发情况。
结论新辅助放化疗能明显降低肿瘤分期，并能使部分患者获得cCR。对于cCR病例，不建议非手术治疗。

Abstract:
Objective To discuss treatment of complete response cases after neoadjuvant radiotherapy in rectal cancer.
Methods This retrospective study analyzed clinical data of 84 rectal cancer cases with pre-operative neoadjuvant chemoradiotherapy in our hospital from January 2010 to Augnst 2014.
Results After neoadjuvant chemoradiotherapy, 33 patients presented clinically complete response at a rate of 39.3%. After post-operative pathologic examination, among clinically complete response cases, six cases exhibited pathologically complete responses at a rate of 18.2%. No recurrence or disease progression occurred within 12-36 months of post-operative follow up.
Conclusion Neoadjuvant chemoradiotherapy can significantly lower tumor stage and promote clinically complete remission of some patients. However, for clinically complete remission cases, further radical surgery should be provided.

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