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摘要: 作为调节性T细胞中最重要的转录因子,转录因子叉头蛋白(forkheadbox protein 3,FOXP3)在T细胞研究领域已被广泛关注。然而最新研究表明,FOXP3在多种肿瘤组织中均有表达,在不同肿瘤中的表达量及发挥的功能亦不相同,部分肿瘤中FOXP3作为抑癌基因抑制肿瘤的增殖与转移,部分肿瘤中则作为癌基因促进肿瘤免疫逃逸。本文总结了FOXP3在不同肿瘤组织中的表达情况及其功能,旨在为今后FOXP3的研究和靶向治疗提供依据。Abstract: As the most important transcription factor in regulatory T cells, forkheadbox protein 3 (FOXP3) has been extensively investigated in T cells. However, FOXP3, a tumor type-dependent transcription factor, is expressed at different levels in different tumors. In some tumors, FOXP3, as a suppressor, inhibits proliferation and metastasis. In other tumors, FOXP3, as an oncogene, mediates tumor immune escape. In this review, we summarize the expression levels and functions of FOXP3 in different tumor types to provide evidence for further research.
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Key words:
- cancer /
- transcription factor /
- FOXP3 /
- oncogene /
- tumor suppressor gene
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表 1 FOXP3在不同肿瘤中的表达、作用及相关分子
Table 1. Expression and function of cancer-FOXP3 in different human tumors with relevant molecules and pathways
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