微管相关蛋白2在胰腺神经内分泌肿瘤组织中的表达及预后意义

宋甜甜; 肖雨; 白春梅; 李乃适; 陈洁; 赵大春; 宋玉立; 金凯舟; 朱丽明; 于润; 虞先濬; 陈原稼

doi:10.3969/j.issn.1000-8179.2017.11.190

微管相关蛋白2在胰腺神经内分泌肿瘤组织中的表达及预后意义

Expression of microtubule-associated protein 2 correlates with better prognosis of pancreatic neuroendocrine tumors

摘要

摘要:
目的探索微管相关蛋白2（microtubule-associated protein 2，MAP2）与微管相关蛋白1B（microtubule-associated protein 1B，MAP1B）在预测胰腺神经内分泌肿瘤（pancreatic neuroendocrine tumors，PNETs）患者预后中的意义。
方法收集1999年12月至2016年12月来自于北京协和医院、中山大学附属第一医院、复旦大学上海癌症中心和Cedars-Sinai医学中心（洛杉矶）193例患者的193个原发肿瘤标本。免疫组织化学染色法分别检测193例、120例PNETs组织中MAP2、MAP1B的表达，随后分析蛋白表达与患者临床病理特征及预后的关系。
结果 MAP2和MAP1B在PNETs患者中的阳性率分别为45.6%（88/193）和64.2%（77/120）。MAP2表达阳性的患者的总生存好于阴性患者（P=0.012）。另外，MAP2阳性Ⅱ、Ⅲ期患者的总生存也优于阴性者（P=0.017）。然而，MAP1B的表达与肿瘤大小、转移、肿瘤组织学分级、临床分期、总生存、无病生存均无相关性（P > 0.05）。
结论 MAP2为潜在的预测PNETs患者预后的指标。

Abstract:
Objective To determine whether microtubule-associated protein 2 (MAP2) and microtubule-associated protein 1B (MAP1B) could be prognostic biomarkers for patients with pancreatic neuroendocrine tumors (PNETs).

Methods With immunohistochemical staining, the expressions of MAP2 and MAP1B were examined in 193 and 120 primary tumors and peritumoral tissues, respectively. Then, the relationship between the expression of each protein and clinicopathological characteristics, including prognosis was analyzed.

Results MAP2 and MAP1B were expressed in 88 of 193 (45.6%) and 77 of 120 (64.2%) tumors, respectively. The expression of MAP2 was significantly associated with the favorable overall survival of patients with PNETs (P=0.012). Moreover, MAP2 expression was associated with the improved overall survival in a subset of patients with stage Ⅱ and stage Ⅲ tumors (P=0.017). The MAP1B expression did not correlate with other clinicopathological features and prognosis.

Conclusion MAP2 could be a novel, independent prognostic biomarker for PNETs.

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