射频消融治疗符合米兰标准的早期肝癌疗效分析

崔芒芒; 朱晓琳; 张倜; 武强; 崔云龙; 李慧锴; 李强; 房锋; 张伟; 宋天强

doi:10.3969/j.issn.1000-8179.2017.11.256

射频消融治疗符合米兰标准的早期肝癌疗效分析

Efficacy analysis of radiofrequency ablation in the treatment of early-stage hepatocellular carcinoma within the Milan criteria

摘要

摘要:
目的探讨射频消融治疗符合米兰标准的早期肝癌的疗效及预后危险因素。
方法回顾性分析天津医科大学肿瘤医院72例行射频消融治疗的符合米兰标准的早期肝癌患者病例，评估其术后恢复情况，分析复发率、生存率及预后危险因素。
结果 72例患者术后并发症轻微且恢复迅速，术后1、2、3年累积复发率分别为12.50%、20.83%和33.33%；1、2、3年累积生存率分别为93.06%、87.50%、79.17%。多因素分析提示肿瘤大小与复发密切相关，肿瘤大小与术前白蛋白水平是影响总生存的独立危险因素。
结论射频消融术治疗符合米兰标准的早期肝癌，近远期效果良好。肿瘤大小是复发的独立危险因素，肿瘤大小与术前白蛋白水平是影响总生存的重要因素。

Abstract:
Objective To assess efficiency of radiofrequency ablation (RFA) in the treatment of early-stage hepatocellular carcinoma within the Milan criteria and analyze prognostic factors.
Methods Reviews were conducted on clinical data of 72 patients with earlystage hepatocellular carcinoma meeting the Milan criteria who underwent RFA in Tianjin Medical University Cancer Institute and Hospital. Recovery status after RFA was assessed, as well as recurrence rate, survival rate, and risk factors associated with prognosis were analyzed.
Results Slight post-RFA complications were observed, and all 72 patients recovered rapidly. For 1-, 2-, and 3-year cumulative recurrence rates, computed values reached 12.50%, 20.83%, and 33.33%, respectively. For 1-, 2-, and 3-year cumulative survival rates, computed values totaled 93.06%, 87.50%, and 79.17%, respectively. Multivariate analysis showed that tumor size was closely associated with recurrence and that tumor size and serum albumin levels before RFA were predictive factors for overall survival.
Conclusion RFA is an effective method in treatment of early-stage hepatocellular carcinoma within the Milan criteria. Tumor size is an independent risk factor of recurrence and along with preoperative serum albumin levels, it is a significant factor affecting overall survival of patients.

HTML全文

参考文献(27)

施引文献

资源附件(0)