乳腺癌靶向治疗的临床进展和未来

徐兵河

徐兵河. 乳腺癌靶向治疗的临床进展和未来[J]. 中国肿瘤临床, 2017, 44(13): 625-629. doi: 10.3969/j.issn.1000-8179.2017.13.121
引用本文: 徐兵河. 乳腺癌靶向治疗的临床进展和未来[J]. 中国肿瘤临床, 2017, 44(13): 625-629. doi: 10.3969/j.issn.1000-8179.2017.13.121
XU Binghe. Clinical progress and future of targeted therapy for breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 44(13): 625-629. doi: 10.3969/j.issn.1000-8179.2017.13.121
Citation: XU Binghe. Clinical progress and future of targeted therapy for breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 44(13): 625-629. doi: 10.3969/j.issn.1000-8179.2017.13.121

乳腺癌靶向治疗的临床进展和未来

doi: 10.3969/j.issn.1000-8179.2017.13.121
详细信息
    作者简介:

    徐兵河教授,主任医师,博士研究生导师。现任国家癌症中心/中国医学科学院、北京协和医学院肿瘤医院内科主任、国家抗肿瘤药物临床研究中心(GCP中心)副主任,兼任中国临床肿瘤学会常务理事、中国抗癌协会乳腺癌专业委员会主任委员、中国抗癌协会肿瘤药物临床研究专业委员会主任委员(候任)、北京乳腺病防治学会理事长、国家药典委员会委员、国家食品药品监督管理局新药审评专家、国家“重大新药创制”科技重大专项论证委员会成员,国家科技重大专项、国家自然科学基金、国家科学技术进步奖、中华医学科技奖评审专家等职。担任《中国肿瘤临床与康复》副总编辑、《中华乳腺病杂志》副总编辑、Translational Cancer Research副主编、The International Journal of Biological Markers等10余种国内外期刊编委。以第一或通讯作者发表论文302篇,其中SCI论文78篇。主编《乳腺癌》等专著以及普通高等学校教材8部。获得全国优秀著作一等奖以及中国抗癌协会、中华医学会、中国药学会、教育部、北京市等多项科技进步奖

    通讯作者:

    徐兵河; E-mail: xubinghe@csco.org.cn

Clinical progress and future of targeted therapy for breast cancer

More Information
  • 摘要: 靶向治疗是乳腺癌最重要的治疗手段之一。近年来针对不同亚型乳腺癌开发了越来越多的分子靶向治疗药物,这些药物的临床应用改善了乳腺癌的治疗效果,并不断改变乳腺癌的临床实践过程。如何克服肿瘤的耐药性以及开发出能够超越传统靶向药物疗效的新药是今后的重要研究方向。

     

  • [1] Johnston S, Pippen J, Pivot X, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer [J]. J Clin Oncol, 2009, 27(33):5538-5546. doi: 10.1200/JCO.2009.23.3734
    [2] Yardley DA, Noguchi S, Pritchard KI, et al. Everolimus plus exemestane in postmenopausal patients with HR+breast cancer: bolero-2 final progression-free survival analysis[J]. Adv Ther, 2013, 30(10):870-884. doi: 10.1007/s12325-013-0060-1
    [3] Finn RS, Martin M, Rugo HS, et al. PALOMA-2: Primary results from a phase Ⅲ trial of palbociclib (P) with letrozole (L) compared with letrozole alone in postmenopausal women with ER+/HER-2-advanced breast cancer (ABC)[J]. J Clin Oncol, 2016, 34(suppl):abstr 507. doi: 10.1200/JCO.2016.34.15_suppl.507
    [4] Hortobagyi GN, Stemmer SM, Burris HA, et al. Ribociclib as FirstLine Therapy for HR-Positive, Advanced Breast Cancer[J]. N Engl J Med, 2016, 375(18):1738-1748. doi: 10.1056/NEJMoa1609709
    [5] Hortobagyi GN, Stemmer SM, Burris HA, et al. Ribociclib as firstline therapy for HR-positive, advanced breast cancer[J]. N Engl J Med, 2016, 375(18):1738-1748. doi: 10.1056/NEJMoa1609709
    [6] Robertson JFR, Bondarenko IM, Trishkina PR, et al. Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial[J]. Lancet, 2017, 388(10063):2997-3005. http://www.medicinesresources.nhs.uk/en/Medicines-Awareness/Primary-Research/Randomised-controlled-trials/Fulvestrant-500-mg-versus-anastrozole-1-mg-for-hormone-receptor-positive-advanced-breast-cancer-FALCON-an-international--6361603656/
    [7] Ro J, Andre F, Loi S, et al. PALOMA3: A double-blind, phase Ⅲ trial of fulvestrant with or without palbociclib in pre-and post-menopausal women with hormone receptor-positive, HER-2-negative metastatic breast cancer that progressed on prior endocrine therapy[J]. J Clin Oncol, 2015, 33(18 suppl):502. doi: 10.1200/jco.2015.33.18_suppl.lba502
    [8] Ozaki A, Tanimoto T, Saji S. Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer[J]. N Engl J Med, 2015, 373(17):209-219. doi: 10.1056/NEJMoa1505270
    [9] Slamon DJ, Leyland-Jones B, Shak S, et al. Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2[J]. N Engl J Med, 2001, 344(11):783-792. doi: 10.1056/NEJM200103153441101
    [10] Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER-2-positive breast cancer[J]. New Engl J Med, 2005, 353(16):1673-1684. doi: 10.1056/NEJMoa052122
    [11] Semiglazov V, Eiermann W, Zambetti M, et al. Surgery following neoadjuvant therapy in patients with HER-2-positive locally advanced or inflammatory breast cancer participating in the NeOAdjuvant Herceptin (NOAH) study[J]. Eur J Surg Oncol, 2011, 37(10):856-863. doi: 10.1016/j.ejso.2011.07.003
    [12] Chan A, MD, Delaloge S, Holmes FA, et al. Neratinib after trastuzumab-based adjuvant therapy in patients with HER-2-positive breast cancer (ExteNET): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial[J]. Lancet Oncol, 2016, 17(3):367-377. doi: 10.1016/S1470-2045(15)00551-3
    [13] Cameron D, Casey M, Press M, et al. A phase Ⅲ randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses[J]. Breast Cancer Res Treat, 2008, 112(3):533-543. doi: 10.1007/s10549-007-9885-0
    [14] Giordano SB, Kaklamani V. Lapatinib in combination with paclitaxel for the treatment of patients with metastatic breast cancer whose tumors overexpress HER-2[J]. Breast Cancer Manag, 2013, 2(6):529-535. doi: 10.2217/bmt.13.55
    [15] Harbeck N, Huang CS, Hurvitz S, et al. Afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER-2-overexpressing metastatic breast cancer who had progressed on one previous trastuzumab treatment (LUX-Breast 1): an open-label, randomised, phase 3 trial[J]. Lancet Oncol, 2016. 17(3):357-366. doi: 10.1016/S1470-2045(15)00540-9
    [16] Baselga J, Cortés J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer[J]. New Engl J Med, 2012, 366 (2):109-119. doi: 10.1056/NEJMoa1113216
    [17] Pegram MD, Blackwell K, Miles D, et al. Primary results from EMILIA, a phase Ⅲ study of trastuzumab emtansine (T-DM1) versus capecitabine (X) and lapatinib (L) in HER-2-positive locally advanced or metastatic breast cancer (MBC) previously treated with trastuzumab (T) and a taxane[J]. J Clin Oncol, 2012, 30(14 Suppl):98.
    [18] Ellis PA, Barrios CH, Eiermann W, et al. Phase Ⅲ, randomized study of trastuzumab emtansine (T-DM1) {+/-} pertuzumab (P) vs trastuzumab+taxane (HT) for first-line treatment of HER-2-positive MBC: primary results from the MARIANNE study[J]. J Clin Oncol, 2015, 33 (suppl):Abstract 507. https://www.researchgate.net/publication/279022015_Phase_II_Randomized_Study_of_Trastuzumab_Emtansine_Versus_Trastuzumab_Plus_Docetaxel_in_Patients_With_Human_Epidermal_Growth_Factor_Receptor_2-Positive_Metastatic_Breast_Cancer
    [19] O'Regan R, Ozguroglu M, Andre F, et al. Phase Ⅲ, randomized, doubleblind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer(BOLERO-3)[J]. J Clin Oncol, 2013, 31(15 Suppl): 505. http://meetinglibrary.asco.org/content/82095
  • 加载中
计量
  • 文章访问数:  131
  • HTML全文浏览量:  17
  • PDF下载量:  9
  • 被引次数: 0
出版历程
  • 收稿日期:  2017-02-03
  • 修回日期:  2017-03-24
  • 刊出日期:  2017-07-15

目录

    /

    返回文章
    返回