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摘要: hormone-receptor-positive breast cancer; hormone therapy; target therapy年轻乳腺癌较老年乳腺癌侵袭性更强，预后更差，但年龄界限并不清晰，年龄作为预后因素是否为连续性变量仍需论证。其中年轻妊娠相关性乳腺癌患者具有特殊的临床及预后特征。本文将25岁及以下乳腺癌定义为极年轻乳腺癌（very young breast cancer，VYBC），对其遗传学因素、临床病理特征、预后、治疗以及妊娠相关性乳腺癌等进行综述，以期为更佳治疗选择提供帮助。Abstract: Breast cancer in younger patients exhibits stronger invasiveness and poorer outcomes compared with that in elders. Cut-off for young age remains unclear, and its basis as prognostic factor representing a continuous variable requires further investigation. Pregnancy-associated breast cancer in young patients also possesses unique biological features. In this review, we define breast cancer diagnosed in patients below 25 years old as very young breast cancer and summarize recent studies based on genetic factors, clinicopathology, prognostic characteristics, and pregnancy-associated breast cancer to assist in management of very young breast cancer patients.
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Key words:
- breast cancer /
- young age /
- immunohistochemistry /
- prognosis /
- therapy
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表 1 25岁以下乳腺癌病例系列汇总
Table 1. Case series of breast cancer patients aged 25 years and younger
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