郑霞, 刘冰冰, 孟凡凡, 李帅, 谷峰, 付丽. 乳腺浸润性微乳头状癌组织β1 integrin及Rac1和RhoA表达的研究[J]. 中国肿瘤临床, 2017, 44(14): 695-700. DOI: 10.3969/j.issn.1000-8179.2017.14.356
引用本文: 郑霞, 刘冰冰, 孟凡凡, 李帅, 谷峰, 付丽. 乳腺浸润性微乳头状癌组织β1 integrin及Rac1和RhoA表达的研究[J]. 中国肿瘤临床, 2017, 44(14): 695-700. DOI: 10.3969/j.issn.1000-8179.2017.14.356
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ZHENG Xia, LIU Bingbing, MENG Fanfan, LI Shuai, GU Feng, FU Li. Expression of β1 integrin, Rac1, and RhoA in invasive micropapillary breast carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 44(14): 695-700. DOI: 10.3969/j.issn.1000-8179.2017.14.356
Citation: ZHENG Xia, LIU Bingbing, MENG Fanfan, LI Shuai, GU Feng, FU Li. Expression of β1 integrin, Rac1, and RhoA in invasive micropapillary breast carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 44(14): 695-700. DOI: 10.3969/j.issn.1000-8179.2017.14.356
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乳腺浸润性微乳头状癌组织β1 integrin及Rac1和RhoA表达的研究

Expression of β1 integrin, Rac1, and RhoA in invasive micropapillary breast carcinoma

    摘要
  • 摘要:
      目的  探讨极性蛋白β1 integrin及Rac1和RhoA在乳腺浸润性微乳头状癌（invasive micropapillary carcinoma，IMPC）组织中的表达及其意义。
      方法  采用免疫组织化学法检测天津医科大学肿瘤医院自2007年1月至2008年12月89例乳腺IMPC患者组织中β1 integrin、Rac1及RhoA的表达，并选取该院同期诊断的90例乳腺浸润性导管癌非特殊型（invasive ductal carcinoma-not other? wise specified，IDC-NOS）病例作为对照，分析3种蛋白间及其与临床病理学特征之间的关系。
      结果  IMPC组织中β1 integrin及Rac1蛋白高表达率分别为78.7%（70/89）和76.4%（68/89），显著高于IDC-NOS组织的63.3%（57/90）和54.4%（49/90），差异均具有统计学意义（P < 0.05）；IMPC组织中RhoA阳性表达率为68.5%（61/89），显著高于IDC-NOS组织的44.4%（40/90），差异亦具有统计学意义（P=0.001）。IMPC组织中β1 integrin与Rac1表达均与淋巴结转移呈正相关（P < 0.05），且二者之间呈正相关（P=0.006）；RhoA表达与淋巴结转移、ER及PR呈正相关（P < 0.05），但与β1 integrin及Rac1的表达无显著相关性（P>0.05）。
      结论  极性蛋白β1 integrin、Rac1及RhoA在乳腺IMPC组织中过表达，提示其可能均在IMPC的高转移中发挥重要作用，且可能成为靶向治疗研究的新靶点。

     

    Abstract:
      Objective  To investigate the expression and significance of β1 integrin, Rac1, and RhoA in invasive micropapillary breast carcinoma (IMPC).
      Methods  Immunohistochemical staining was performed to detect the expression of β1 integrin, Rac1, and RhoA in 89 patients with IMPC and 90 patients with invasive ductal carcinoma-not otherwise specified (IDC-NOS) who were treated between January 2007 and December 2008 in Tianjin Medical University Cancer Institute and Hospital. The relationship among the three proteins and the expression of β1 integrin, Rac1, and RhoA with clinicopathological features were determined.
      Results  β1 integrin (78.7%) and Rac1 (76.4%) were highly expressed in patients with IMPC. This expression was significantly higher than that in patients with IDC-NOS (63.3% and 54.4%). Statistical difference was found between the two groups (P < 0.05). Positive rate of RhoA (68.5%) in patients with IMPC was also statistically higher than that in patients with IDC-NOS (44.4%, P=0.001). In patients with IMPC, the expression of β1 integrin and Rac1 was positively associated with lymph node metastasis (P < 0.05), while the expression of β1 integrin was positively correlated with Rac1 expression (P=0.006). Expression of RhoA was positively correlated with lymph node involvement and ER and PR status (P < 0.05). However, no correlation was found between RhoA expression and the expression of β1 integrin and Rac1 (P>0.05).
      Conclusion  Thus, β1 integrin, Rac1, and RhoA were overexpressed and might play an important role in the high frequency of metastasis in patients with IMPC. These proteins could be considered as biomarkers for the prognosis and new targets for IMPC therapy.

     

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