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摘要: 正常情况下，人体肠道内菌群保持相对稳定的状态，共生菌、益生菌和病原菌的比例维持相对稳定。肠道菌群失调可改变肠道内的生理环境，还能通过各种途径引起人体肠外组织器官生理状态的改变，甚至影响肿瘤的发生发展。脑肠轴是其中一条通路，由免疫、代谢、神经内分泌和迷走神经等途径构成。本文旨在讨论肿瘤和肠道菌群之间的关系以及肠道菌群通过脑肠轴的4条途径改变机体的应激水平，从而影响肿瘤发生发展的相关机制，同时就肠道菌群调控在肿瘤治疗中的作用进行了探讨。Abstract: Under normal circumstances, the gut microbiota and the proportion of symbiotic bacteria, probiotics, and pathogens remain relatively stable, but dysbiosis in the gut can change not only the physiological environment of the intestine but also the physiological state of some distant tissues and organs.This condition can even lead to tumor development.Gut-brain axis is a pathwaythrough which gut microbiota can influence tumor growth and is associated with other pathways, such as immune, metabolic, neuroendocrine, and vagal neural pathways.This paper reports the relationship between tumor growth and microbial groups in the gut andthe mechanisms of gut dysbiosis inducing a chronic stress state via the gut–brain axis, which affects tumor development.This paperalso presents the role of gut microbiota in tumor treatment.
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Key words:
- gut microbiota /
- gut-brain axis /
- chronic stress /
- tumor
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[1] Zitvogel L, Galluzzi L, Viaud S, et al.Cancer and the gut microbiota:An unexpected link[J].Sci Transl Med, 2015, 7(271):271. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690201/ [2] Gaboriau-Routhiau V, Cerf-Bensussan N.The immune system andthe gut microbiota: friends or foes[J]? Nat Rev Immunol, 2010, 10(10):735-744. doi: 10.1038/nri2850 [3] Foster JA, Mcvey Neufeld KA.Gut-brain axis: how the microbiome influences anxiety and depression[J].Trends Neurosci, 2013, 36(5):305-312. doi: 10.1016/j.tins.2013.01.005 [4] Clemente JC, Ursell LK, Parfrey LW, et al.The impact of the gut microbiota on human health: an integrative view[J].Cell, 2012, 148(6):1258-1270. doi: 10.1016/j.cell.2012.01.035 [5] Naseribafrouei A, Hestad K, Avershina E, et al.Correlation betweenthe human fecal microbiota and depression[J].Neurogastroenterol Motil, 2014, 26(8):1155-1162. doi: 10.1111/nmo.2014.26.issue-8 [6] Mayer EA, Knight R, Mazmanian SK, et al.Gut microbes and thebrain: paradigm shift in neuroscience[J].J Neurosci, 2014, 34(46):15490-15496. doi: 10.1523/JNEUROSCI.3299-14.2014 [7] Sharon G, Sampson TR, Geschwind DH, et al.The central nervoussystem and the gut microbiome[J].Cell, 2016, 167(4):915-932. doi: 10.1016/j.cell.2016.10.027 [8] Kelly JR, Borre Y, O'Brien C, et al.Transferring the blues: depressionassociated gut microbiota induces neurobehavioural changes inthe rat[J].J Psychiatr Res, 2016, (82):109-118. http://www.journalofpsychiatricresearch.com/article/S0022-3956(16)30157-1/abstract [9] Chida Y, Hamer M, Wardle J, et al.Do stress-related psychosocialfactors contribute to cancer incidence and survival[J]? Nat ClinPract Oncol, 2008, 5(8):466-475. doi: 10.1038/ncponc1134 [10] Medzhitov R.Recognition of microorganisms and activation of theimmune response[J].Nature, 2007, 449(7164):819-826. doi: 10.1038/nature06246 [11] Bercik P, Verdu EF, Foster JA, et al.Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice[J].Gastroenterology, 2010, 139(6):2102-2112. doi: 10.1053/j.gastro.2010.06.063 [12] Moreno-Smith M, Lutgendorf SK, Sood AK.Impact of stress on cancer metastasis[J].Future Oncol, 2010, 6(12):1863-1881. doi: 10.2217/fon.10.142 [13] Kelly JR, Kennedy PJ, Cryan JF, et al.Breaking down the barriers: thegut microbiome, intestinal permeability and stress-related psychiatric disorders[J].Front Cell Neurosci, 2015, (9):392. https://www.ncbi.nlm.nih.gov/pubmed/26528128 [14] Sudo N, Chida Y, Aiba Y, et al.Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice[J].J Physiol, 2004, 558(Pt 1):263-275. https://www.ncbi.nlm.nih.gov/pubmed/15133062?f1000m,isrctn [15] Thaker PH, Sood AK.Neuroendocrine influences on cancer biology[J].Semin Cancer Biol, 2008, 18(3):164-170. doi: 10.1016/j.semcancer.2007.12.005 [16] Cryan JF, Kaupmann K.Don't worry 'B' happy: a role for GABAB receptors in anxiety and depression[J].Trends Pharmacol Sci, 2005, 26(1):36-43. doi: 10.1016/j.tips.2004.11.004 [17] Thaker PH, Yokoi K, Jennings NB, et al.Inhibition of experimental colon cancer metastasis by the GABA-receptor agonist nembutal[J].Cancer Biol Ther, 2005, 4(7):753-758. doi: 10.4161/cbt.4.7.1827 [18] Al-Wadei HAN, Plummer HK, Ullah MF, et al.Social stress promotes and-aminobutyric acid inhibits tumor growth in mouse models of nonsmall cell lung cancer[J].Cancer Prev Res(Phila), 2012, 5(2):189-196. doi: 10.1158/1940-6207.CAPR-11-0177 [19] Barrett E, Ross RP, O'Toole PW, et al.γ-Aminobutyric acid production by culturable bacteria from the human intestine[J].J Appl Microbiol, 2012, 113(2):411-417. doi: 10.1111/jam.2012.113.issue-2 [20] Nemeroff CB, Mayberg HS, Krahl SE, et al.VNS therapy in treatmentresistant depression: clinical evidence and putative neurobiological mechanisms[J].Neuropsychopharmacology, 2006, 31(7):1345-1355. doi: 10.1038/sj.npp.1301082 [21] Bravo JA, Forsythe P, Chew MV, et al.Ingestion of Lactobacillus strainregulates emotional behavior and central GABA receptor expressionin a mouse via the vagus nerve[J].Proc Natl Acad Sci U S A, 2011, 108(38):16050-16055. doi: 10.1073/pnas.1102999108 [22] Erny D, Hrabě De Angelis AL, Jaitin D, et al.Host microbiota constantly control maturation and function of microglia in the CNS[J].Nat Neurosci, 2015, 18(7):965-977. doi: 10.1038/nn.4030 [23] Yirmiya R, Rimmerman N, Reshef R.Depression as a microglial disease[J].Trends Neurosci, 2015, 38(10):637-658. doi: 10.1016/j.tins.2015.08.001 [24] Gianotti L, Morelli L, Galbiati F, et al.A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients[J].World J Gastroenterol, 2010, 16(2):167-175. doi: 10.3748/wjg.v16.i2.167 [25] Limburg PJ, Mahoney MR, Ziegler KL, et al.Randomized phase Ⅱ trialof sulindac, atorvastatin, and prebiotic dietary fiber for colorectalcancer chemoprevention[J].Cancer Prev Res(Phila), 2011, 4(2):259-269. doi: 10.1158/1940-6207.CAPR-10-0215 [26] van Nood E, Vrieze A, Nieuwdorp M, et al.Duodenal infusion of donor feces for recurrent Clostridium difficile[J].N Engl J Med, 2013, 368(5):407-415. doi: 10.1056/NEJMoa1205037 [27] Lida N, Dzutsev A, Stewart CA, et al.Commensal bacteria controlcancer response to therapy by modulating the tumor microenvironment[J].Science, 2013, 342(6161):967-970. doi: 10.1126/science.1240527 [28] Viaud S, Saccheri F, Mignot G, et al.The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide[J].Science, 2013, 342(6161):971-976. doi: 10.1126/science.1240537 [29] Vetizou M, Pitt J M, Daillere R, et al.Anticancer immunotherapy byCTLA-4 blockade relies on the gut microbiota[J].Science, 2015, 350(6264):1079-1084. doi: 10.1126/science.aad1329 [30] Sivan A, Corrales L, Hubert N, et al.Commensal bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy[J].Science, 2015, 350(6264):1084-1089. doi: 10.1126/science.aac4255 [31] Chase D, Goulder A, Zenhausern F, et al.The vaginal and gastrointestinal microbiomes in gynecologic cancers: a review of applications in etiology, symptoms and treatment[J].Gynecol Oncol, 2015, 138(1):190-200. doi: 10.1016/j.ygyno.2015.04.036 [32] Donovan HS, Hagan TL, Campbell GB, et al.Nausea as a sentinelsymptom for cytotoxic chemotherapy effects on the gut-brain axisamong women receiving treatment for recurrent ovarian cancer: anexploratory analysis[J].Support Care Cancer, 2016, 24(6):2635-2642. doi: 10.1007/s00520-015-3071-4 -
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