长链非编码RNA在膀胱尿路上皮癌中的研究进展

张超; 姚欣

doi:10.3969/j.issn.1000-8179.2017.17.451

长链非编码RNA在膀胱尿路上皮癌中的研究进展

doi: 10.3969/j.issn.1000-8179.2017.17.451

张超,
姚欣^,

天津医科大学肿瘤医院泌尿肿瘤科，国家肿瘤临床医学研究中心，天津市肿瘤防治重点实验室，天津市恶性肿瘤临床医学研究中心（天津市300060）

详细信息

作者简介:
张超专业方向为泌尿系肿瘤的外科及综合治疗。E-mail：enzo_zc@163.com

通讯作者:
姚欣 yaoxin1969@hotmail.com

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- 被引次数: 0
出版历程
- 收稿日期: 2017-04-19
- 修回日期: 2017-06-16
- 刊出日期: 2017-09-15

Research progress on long noncoding RNA in urothelial bladder carcinoma

ZHANG Chao,
YAO Xin^,

Department of Genitourinary Oncology, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center forCancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China

More Information

Corresponding author: Xin YAO; E-mail:yaoxin1969@hotmail.com

摘要

摘要: 长链非编码RNA（long noncoding RNA，lncRNA）是一组长度>200bp，缺少特异性开放阅读框，几乎不具备蛋白编码功能的内源性RNA分子。lncRNA可在转录、转录后及表观遗传学水平等方面调控基因表达，从而影响多种生物学进程。膀胱尿路上皮癌中多种lncRNA发挥癌基因或抑癌基因的作用，并与膀胱癌的诊断、治疗、预后及肿瘤细胞的增殖、迁移、侵袭密切相关。本文就膀胱癌中lncRNA的研究进展进行综述，并探讨lncRNA与膀胱癌的发生、发展之间的关系，为寻找膀胱癌分子标志物、药物靶点提供新的方向。
- 膀胱尿路上皮癌 /
- 长链非编码RNA /
- 复发 /
- 转移
Abstract: Long noncoding RNAs(lncRNAs)are endogenous RNA molecules with length of more than 200 bp, without specific openreading frame, and almost without protein coding function.LncRNA can regulate gene expression at transcriptional, post-transcriptional, and epigenetic levels.Thus, this molecule affects diverse biological processes.LncRNA may function as an oncogene or anti-oncogene in urothelial bladder carcinoma.Moreover, this molecule is closely related not only to the diagnosis, treatment, and prognosis ofurothelial bladder carcinoma but also to the proliferation, migration, and invasion of tumor cells.Progress on the study of lncRNA inbladder cancer and the relationship between lncRNA and occurrence and development of bladder cancer was discussed.A new direction for the exploration of molecular markers and targeted therapies for bladder cancer is provided.
- urothelial bladder carcinoma /
- long noncoding RNA /
- recurrence /
- metastasis

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参考文献(25)

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