Abstract:
Objective To evaluate the association between the polymorphisms in TP63 rs6790167 and lung cancer.
Methods We performed a case-control study with 258 patients and 270 controls. Genomic DNA was extracted using a blood genome extraction kit. Genotyping was conducted using allele-specific polymerase chain reaction (AS-PCR).
Results No significant difference was observed in the genotype of TP63 rs6790167 between cases and controls, and allele frequencies significantly elevated in the cases (P=0.045). In a further stratified analysis by gender and smoking status, the frequencies of the GG genotype and G allele of rs6790167 were significantly higher in non-smoking male patients with lung adenocarcinoma (P=0.000, P=0.001), individuals with GG genotype had a higher risk for lung adenocarcinoma in non-smoking man (OR=6.66, 95% CI: 2.16-20.41). Individuals with G allele had a higher risk for lung adenocarcinoma in a non-smoking man (OR=2.54, 95% CI: 1.42-4.56) in comparison with individuals with A allele.
Conclusion We found that the polymorphisms of TP63 rs6790167 were associated with the risk for lung adenocarcinoma in non-smoking men and that these polymorphisms may be a predictor for lung adenocarcinoma in non-smoking men.