TP63 rs6790167多态性与海南汉族人肺癌的相关性研究

唐文军; 闫其星; 王天柱; 易国辉; 薛丽; 林海锋

doi:10.3969/j.issn.1000-8179.2017.21.400

TP63 rs6790167多态性与海南汉族人肺癌的相关性研究

Association of the polymorphisms in TP63 rs6790167 with risk for lung cancer in Hainan Han population

摘要

摘要:
目的探讨TP63 rs6790167多态性与海南汉族人肺癌之间的相关性。
方法收集2014年6月至2015年7月258例海南医学院第二附属医院就诊的肺癌患者和270例健康对照者的外周静脉血，采用病例对照研究的方法，提取血液基因组DNA，应用等位基因特异性聚合酶链反应（allele-specific PCR，AS-PCR）法检测肺癌组和对照组人群的TP63 rs6790167位点的多态基因型。
结果肺癌组中TP63 rs6790167位点的G等位基因分布频率明显高于对照组（P=0.045）。进一步分层分析显示，在肺腺癌组中，非吸烟男性的GG基因型分布和G等位基因的分布频率均显著高于对照组（P < 0.001，P=0.001），携带GG基因型的非吸烟男性的肺腺癌发病风险与AA基因型相比明显升高（OR=6.66，95%CI为2.16~20.41），相对于TP63 rs6790167位点的A等位基因，携带G等位基因的非吸烟男性的肺腺癌发病风险显著增加（OR=2.54，95%CI为1.42~4.56）。
结论 TP63 rs6790167多态性与肺腺癌的发生有关，对非吸烟男性人群肺腺癌的发生可能具有预测作用。

Abstract:
Objective To evaluate the association between the polymorphisms in TP63 rs6790167 and lung cancer.
Methods We performed a case-control study with 258 patients and 270 controls. Genomic DNA was extracted using a blood genome extraction kit. Genotyping was conducted using allele-specific polymerase chain reaction (AS-PCR).
Results No significant difference was observed in the genotype of TP63 rs6790167 between cases and controls, and allele frequencies significantly elevated in the cases (P=0.045). In a further stratified analysis by gender and smoking status, the frequencies of the GG genotype and G allele of rs6790167 were significantly higher in non-smoking male patients with lung adenocarcinoma (P=0.000, P=0.001), individuals with GG genotype had a higher risk for lung adenocarcinoma in non-smoking man (OR=6.66, 95% CI: 2.16-20.41). Individuals with G allele had a higher risk for lung adenocarcinoma in a non-smoking man (OR=2.54, 95% CI: 1.42-4.56) in comparison with individuals with A allele.
Conclusion We found that the polymorphisms of TP63 rs6790167 were associated with the risk for lung adenocarcinoma in non-smoking men and that these polymorphisms may be a predictor for lung adenocarcinoma in non-smoking men.

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