颜彬, 陈慧君, 高晗, 谭文福, 蔡鸿宁, 周志刚, 戴璇, 朱发霞, 熊雨静, 徐檬, 郭玉琳, 邹苗, 吴绪峰. 肿瘤相关CD66b阳性中性粒细胞对预测宫颈癌Ⅰb至Ⅱa期复发的价值[J]. 中国肿瘤临床, 2017, 44(21): 1071-1075. DOI: 10.3969/j.issn.1000-8179.2017.21.598
引用本文: 颜彬, 陈慧君, 高晗, 谭文福, 蔡鸿宁, 周志刚, 戴璇, 朱发霞, 熊雨静, 徐檬, 郭玉琳, 邹苗, 吴绪峰. 肿瘤相关CD66b阳性中性粒细胞对预测宫颈癌Ⅰb至Ⅱa期复发的价值[J]. 中国肿瘤临床, 2017, 44(21): 1071-1075. DOI: 10.3969/j.issn.1000-8179.2017.21.598
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YAN Bin, CHEN Huijun, GAO Han, TAN Wenfu, CAI Hongning, ZHOU Zhigang, DAI Xuan, ZHU Faxia, XIONG Yujing, XU Meng, GUO Yulin, ZOU Miao, WU Xufeng. Value of tumor-associated CD66b-positive neutrophils for the prediction of the recurrence of stage Ⅰb and Ⅱa cervical cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 44(21): 1071-1075. DOI: 10.3969/j.issn.1000-8179.2017.21.598
Citation: YAN Bin, CHEN Huijun, GAO Han, TAN Wenfu, CAI Hongning, ZHOU Zhigang, DAI Xuan, ZHU Faxia, XIONG Yujing, XU Meng, GUO Yulin, ZOU Miao, WU Xufeng. Value of tumor-associated CD66b-positive neutrophils for the prediction of the recurrence of stage Ⅰb and Ⅱa cervical cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 44(21): 1071-1075. DOI: 10.3969/j.issn.1000-8179.2017.21.598
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肿瘤相关CD66b阳性中性粒细胞对预测宫颈癌Ⅰb至Ⅱa期复发的价值

Value of tumor-associated CD66b-positive neutrophils for the prediction of the recurrence of stage Ⅰb and Ⅱa cervical cancer

    摘要
  • 摘要:
      目的  ：探讨宫颈癌组织中的多形核嗜中性粒细胞（polymorphnuclear neutrophil，PMN）数量在预测宫颈癌复发中的作用。
      方法  回顾性分析1999年2月至2006年12月湖北省妇幼保健院及武汉大学中南医院92例初治宫颈癌Ⅰb~Ⅱa期患者的临床病理资料。采用免疫组织化学法检测宫颈癌组织中阳性CD66b的PMN数量，计算PMN数量平均值。将患者按宫颈癌组织中PMN浸润数量分组，数量 > PMN平均值为A组，数量≤PMN平均值为B组。以无复发生存（recurrence free survival，RFS）为结点，采用Kaplan-Meier法进行单因素分析，采用Cox风险回归模型进行多因素分析。
      结果  A组的RFS期明显短于B组（P=0.001）。单因素及Cox风险回归模型多因素分析结果显示，腺癌（HR为3.020，95%CI为1.340~6.805，P=0.008）、淋巴结转移（HR为2.450，95%CI为1.065~5.637，P=0.035）、PMN浸润数量增加（HR为2.866，95%CI为1.274~46.447，P=0.011）为宫颈癌患者RFS的独立危险因素。
      结论  宫颈癌组织中PMN数量的增加与宫颈癌患者RFS期缩短相关，是宫颈癌患者预后不良的一个潜在预测指标。

     

    Abstract:
      Objective  To investigate the prognostic effect of polymorphnuclear neutrophil (PMN) in cervical cancer.
      Methods  Patients (n=92) who underwent curative surgery for the treatment of stage Ⅰb and Ⅱa cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) were assessed to determine their tumor-infiltrating CD66b-positive neutrophils through immunohistochemistry. Assessment results were then analyzed to identify their correlation with recurrence-free survival (RFS) as an end point. Kaplan–Meier method was used for survival curve analysis, and a Cox proportional hazard model was utilized for univariate and multivariate analyses.
      Results  The RFS of the group with a density of CD66b-positive neutrophils above the median in cervical cancer tissues was significantly shorter than that of the group with a density of CD66b-positive neutrophils below the median (P=0.001). Univariate and multivariate analyses revealed adenocarcinoma (HR=3.020; 95% CI=1.340-6.805; P=0.008), lymph node metastasis (HR=2.450; 95% CI=1.065-5.637; P=0.035), and high neutrophil density (HR=2.866; 95% CI=1.274-46.447; P=0.011) as independent prognostic factors of short RFS.
      Conclusion  The increasing number of tumor-infiltrating neutrophils in cervical cancer tissues was correlated with short RFS of patients with cervical cancer.

     

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