Abstract:
Objective To investigate the prognostic effect of polymorphnuclear neutrophil (PMN) in cervical cancer.
Methods Patients (n=92) who underwent curative surgery for the treatment of stage Ⅰb and Ⅱa cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) were assessed to determine their tumor-infiltrating CD66b-positive neutrophils through immunohistochemistry. Assessment results were then analyzed to identify their correlation with recurrence-free survival (RFS) as an end point. Kaplan–Meier method was used for survival curve analysis, and a Cox proportional hazard model was utilized for univariate and multivariate analyses.
Results The RFS of the group with a density of CD66b-positive neutrophils above the median in cervical cancer tissues was significantly shorter than that of the group with a density of CD66b-positive neutrophils below the median (P=0.001). Univariate and multivariate analyses revealed adenocarcinoma (HR=3.020; 95% CI=1.340-6.805; P=0.008), lymph node metastasis (HR=2.450; 95% CI=1.065-5.637; P=0.035), and high neutrophil density (HR=2.866; 95% CI=1.274-46.447; P=0.011) as independent prognostic factors of short RFS.
Conclusion The increasing number of tumor-infiltrating neutrophils in cervical cancer tissues was correlated with short RFS of patients with cervical cancer.