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摘要: 随着分子诊断技术的不断发展，精准治疗已进入恶性肿瘤的治疗范畴，靶向治疗是近年来较为热门的研究方向。神经母细胞瘤（neuroblastoma，NB）是儿童期最常见的颅外实体瘤。研究表明，很多基因参与NB的发生发展过程，T淋巴瘤侵袭转移诱导因子1（T lymphoma invasion and metastasis inducing factor 1，TIAM1）是其中之一。TIAM1主要与下游的RAC1（Ras-related C3 botu?linum toxin substrate 1）结合，作用于TrkA/TIAM1/RAC1通路，激活下游相关因子，参与调节神经元轴突的分化过程。因此，深入的研究和实验或许可以更透彻的阐明具体的机制，为NB未来的诊疗提供一个新的方向。Abstract: With continuous development of molecular diagnosis, "precision treatment" has entered the therapeutic category for malignant tumors, and targeted gene therapy has been an intense research topic in recent years. Neuroblastoma is the most common extracranial solid tumor that develops during childhood. Studies show that many genes, such as TIAM1, are involved in the development and progression of neuroblastoma. TIAM1 mainly combines with RAC1 to activate downstream factors that mediate differentiation via the TrkA/TIAM1/RAC1 signaling pathway, which is involved in the regulation of neurite. Therefore, further studies and experiments may reveal the specific mechanisms and provide a new direction for the future treatment and development of neuroblastoma.
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Key words:
- neuroblastoma /
- children /
- TIAM1 /
- differentiation /
- research progress
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图 1 TrkA/TIAM1/RAC1和P75NG-FR/RhoA信号通路示意图
Figure 1. Schematic of TrkA/TIAM1/RAC1 and P75NGFR/RhoA signaling pathways
表 1 TIAM1主要结构域的基本功能及信号通路
Table 1. The basic functions and signaling pathways of the main domain of the TIAM1
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