Abstract:
Objective To summarize the clinical features of clear cell sarcoma of the kidney(CCSK)in children and to evaluate the efficacy and safety of the WT-2009 chemotherapy protocol.
Methods Clinical data of children with CCSK recorded between January 2009and December 2014 were retrospectively analyzed.Follow-ups were conducted to monitor the postoperative conditions of the patients.
Results Nine cases of CCSK were recruited, and another three cases were excluded for the analysis because of incomplete clinical data.All patients achieved complete remission when the treatment was finished.The estimated 3-year overall survival rate was100%, and the estimated 3-year event-free survival rate was 83.3%.No report is available on the significant side effects associatedwith this treatment.
Conclusion CCSK is rare in children and is easily misdiagnosed.The chemotherapy based on the WT-2009 protocol can produce a favorable prognosis and a high tolerance for patients with CCSK.However, the treatment for high-risk patient needsto be further explored, and follow-ups must be intensified.