徐嵩, 李雄飞, 陈军. 原发性肺类癌的治疗进展与展望[J]. 中国肿瘤临床, 2018, 45(1): 47-52. DOI: 10.3969/j.issn.1000-8179.2018.01.092
引用本文: 徐嵩, 李雄飞, 陈军. 原发性肺类癌的治疗进展与展望[J]. 中国肿瘤临床, 2018, 45(1): 47-52. DOI: 10.3969/j.issn.1000-8179.2018.01.092
Xu Song, Li Xiongfei, Chen Jun. Progress and prospects on treatment of primary pulmonary carcinoid[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(1): 47-52. DOI: 10.3969/j.issn.1000-8179.2018.01.092
Citation: Xu Song, Li Xiongfei, Chen Jun. Progress and prospects on treatment of primary pulmonary carcinoid[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(1): 47-52. DOI: 10.3969/j.issn.1000-8179.2018.01.092

原发性肺类癌的治疗进展与展望

Progress and prospects on treatment of primary pulmonary carcinoid

  • 摘要: 原发性肺类癌(pulmonary carcinoid,PC)是一种较为少见的肺部肿瘤。在2015年世界卫生组织(WHO)最新的肿瘤分类中,PC包括典型类癌(typical carcinoid,TC)和非典型类癌(atypical carcinoid,AC)。PC与大细胞神经内分泌癌(large cell neuroendo? crine carcinoma,LCNEC)和小细胞肺癌(small cell lung carcinoma,SCLC)均属于肺部神经内分泌肿瘤(neuroendocrine tumor,NET)。由于发病率较低,且缺乏特异性的临床表现,PC的诊断和管理相对较复杂。对于整体健康状况和肺储备可以耐受手术的早期局限型PC患者,外科手术切除是首选的治疗方法。而晚期或不可切除PC患者,目前各种指南推荐的标准系统治疗缺乏统一的共识。本文拟对PC最新的诊断及多学科治疗进展进行综述。

     

    Abstract: Primary pulmonary carcinoid tumors are a group of relatively rare lung neoplasms. In the 2015 World Health Organization classification of lung tumors, lung carcinoid tumors (including both the classical and atypical types) were included in the category of pulmonary neuroendocrine tumors along with large cell neuroendocrine carcinomas and small cell lung carcinomas. Due to the low incidence and lack of specific clinical manifestations, the diagnosis and management of pulmonary carcinoid tumors remain relatively challenging. Current consensus supports surgery as the only curative option for localized, resectable pulmonary carcinoid tumors. However, some inconsistencies exist between the guideline recommendations for systemic therapies that have resulted in a lack of consensus in regard to the standardized treatment for the metastatic or unresectable disease. This review intends to summarize the latest recommendations for the diagnosis and multidisciplinary treatment of pulmonary carcinoid tumors.

     

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