Abstract: The liver is a common site of metastasis for a variety of malignant tumors. Although surgery is the first choice among many local treatments, about 80% patients in clinical practice are not suitable for surgical resection due to various reasons. There are also many noninvasive methods, such as chemotherapy, radiofrequency ablation, radiotherapy. Due to poor radiation dose tolerance in the liver, the application of traditional two-dimensional radiotherapy is limited. Recently, with the development of assistive technologies, the use of stereotactic body radiation therapy (SBRT) in cases of liver metastases has gradually increased. Consequently, exploring the optimal patient population, dosage, fraction and safety have become hot topics in this field of research.