黄晓培, 朱江波, 常文军, 张晓芳, 张天宝, 康争春, 薛伟. 外周血粒淋比联合肿瘤相关中性粒细胞对术后胃癌患者预后的影响[J]. 中国肿瘤临床, 2018, 45(2): 77-82. DOI: 10.3969/j.issn.1000-8179.2018.02.043
引用本文: 黄晓培, 朱江波, 常文军, 张晓芳, 张天宝, 康争春, 薛伟. 外周血粒淋比联合肿瘤相关中性粒细胞对术后胃癌患者预后的影响[J]. 中国肿瘤临床, 2018, 45(2): 77-82. DOI: 10.3969/j.issn.1000-8179.2018.02.043
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Huang Xiaopei, Zhu Jiangbo, Chang Wenjun, Zhang Xiaofang, Zhang Tianbao, Kang Zhengchun, Xue Wei. Prognostic significance of preoperative neutrophil-lymphocyte ratio combined with tumor-associated neutrophils in patients with gastric cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(2): 77-82. DOI: 10.3969/j.issn.1000-8179.2018.02.043
Citation: Huang Xiaopei, Zhu Jiangbo, Chang Wenjun, Zhang Xiaofang, Zhang Tianbao, Kang Zhengchun, Xue Wei. Prognostic significance of preoperative neutrophil-lymphocyte ratio combined with tumor-associated neutrophils in patients with gastric cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(2): 77-82. DOI: 10.3969/j.issn.1000-8179.2018.02.043
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外周血粒淋比联合肿瘤相关中性粒细胞对术后胃癌患者预后的影响

Prognostic significance of preoperative neutrophil-lymphocyte ratio combined with tumor-associated neutrophils in patients with gastric cancer

    摘要
  • 摘要:
      目的  探讨胃癌患者外周血中性粒细胞与淋巴细胞比值（neutrophil to lymphocyte ratio，NLR）和胃癌间质肿瘤相关中性粒细胞（tumor-associated neutrophils，TANs）对胃癌患者预后的预测价值。
      方法  选取第二军医大学附属长海医院2006年6月至2011年5月收治的126例胃癌患者，根据术前外周血NLR及胃癌患者TANs的浸润情况，将其分为4个组，比较全组胃癌患者的术后生存率，并分析其与临床病理学特征及预后的相关性。
      结果  NLR高合并TANs低浸润组肿瘤分化程度较低（P < 0.001）且肿瘤体积较大（P=0.026）。4个组中NLR高合并TANs低浸润组生存率最低，NLR低合并TANs高浸润组生存率最高，且差异具有统计学意义（P < 0.05）。单因素及多因素Cox回归分析均显示:NLR高合并TANs低浸润（P < 0.05）是影响胃癌预后的独立危险因素。
      结论  术前外周血NLR联合胃癌组织中TANs浸润可作为判断胃癌患者预后的指标，且术前外周血NLR高联合胃癌组织中TANs低浸润胃癌患者的预后较差。

     

    Abstract:
      Objective  To investigate the prognostic significance of preoperative neutrophil-lymphocyte ratio (NLR) combined with tumor-associated neutrophils (TANs) in the stroma of gastric cancer tissues of patients.
      Methods  One hundred and twenty-six gastric cancer tissue samples from patients enrolled in Changhai hospital from June 2006 to May 2011 were divided into four groups according to NLRs in preoperative peripheral blood combined with high or low infiltration of neutrophils in gastric cancer tissues. The 5-year survival of the four groups was then compared, and their correlations with clinicopathologic features and prognosis were analyzed.
      Results  High NLRs in peripheral blood combined with low infiltrating TANs in gastric tissues was associated with lower differential grade (P < 0.001) and larger tumor size (P=0.026). Of the four groups, patients with high NLR in peripheral blood combined with low infiltrating TANs in gastric cancer tissues demonstrated the lowest survival rates, whereas those with low NLR and high infiltrating TANs had highest survival rates, and this difference was statistically significant (P < 0.05). Univariate and multivariate Cox regression analyses showed that high NLR in peripheral blood combined with low infiltrating TANs in gastric cancer tissues (P < 0.05) was an independent factor indicating poor prognosis.
      Conclusions  NLR in preoperative peripheral blood combined with infiltrating TANs in gastric cancer tissues can be used as a prognostic indicator for patients with gastric cancer, especially high NLR in preoperative peripheral blood combined with low infiltrating TANs in gastric cancer tissue indicates poor prognosis.

     

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