丁群华, 韩保卫, 许震, 孙生安. 胃癌患者术前血小板分布宽度与临床病理特征及预后关系[J]. 中国肿瘤临床, 2018, 45(2): 72-76. DOI: 10.3969/j.issn.1000-8179.2018.02.868
引用本文: 丁群华, 韩保卫, 许震, 孙生安. 胃癌患者术前血小板分布宽度与临床病理特征及预后关系[J]. 中国肿瘤临床, 2018, 45(2): 72-76. DOI: 10.3969/j.issn.1000-8179.2018.02.868
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Ding Qunhua, Han Baowei, Xu Zhen, Sun Shengan. Association of preoperative platelet distribution width with clinicopathologic features and prognosis of gastric cancer patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(2): 72-76. DOI: 10.3969/j.issn.1000-8179.2018.02.868
Citation: Ding Qunhua, Han Baowei, Xu Zhen, Sun Shengan. Association of preoperative platelet distribution width with clinicopathologic features and prognosis of gastric cancer patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(2): 72-76. DOI: 10.3969/j.issn.1000-8179.2018.02.868
shu

胃癌患者术前血小板分布宽度与临床病理特征及预后关系

Association of preoperative platelet distribution width with clinicopathologic features and prognosis of gastric cancer patients

    摘要
  • 摘要:
      目的  活化的血小板参与肿瘤发生和进展，血小板分布宽度（platelet distribution width，PDW）是血小板活化的早期指标。本研究旨在探讨患者术前PDW对判断胃癌预后的价值。
      方法  回顾分析2010年1月至2012年1月郑州大学第二附属医院收治的126例胃癌患者的临床资料。根据ROC曲线确定PDW临界值，分为低PDW组和高PDW组。采用单因素和Cox回归模型进行预后分析，评估PDW与无进展生存期（progression-free survival，PFS）及总生存期（overall survival，OS）的关系。
      结果  两组患者在肿瘤分化程度、血小板计数方面比较，差异具有统计学意义。此外，降低的PDW与胃癌的PFS和OS缩短有关。在多因素Cox回归分析中，高PDW组的患者与低PDW组的患者相比，疾病进展风险下降（HR：0.562；95%CI：0.184~0.926；P=0.012），死亡风险下降（HR：0.468；95%CI：0.263~0.834；P=0.010）。
      结论  术前降低的PDW是胃癌预后不良的因素，可能成为胃癌预后的检测指标。

     

    Abstract:
      Objective  Activating platelets are associated with tumor development and progression. Platelet distribution width (PDW) is an early index of activated platelets. The goal of this study was to investigate the association between prognosis and preoperative PDW in gastric cancer.
      Methods  A total of 126 gastric cancer patients were retrospectively analyzed from January 2010 to January 2012. The optimal cutoff value of PDW was determined by time-dependent receiver-operating curves. The patients were divided into low and high PDW groups. The prognostic analysis was carried out with univariate analysis and the Cox regression model, which evaluated the association of PDW, with progression-free survival (PFS) and overall survival (OS).
      Results  PDW was closely related with differentiation and platelet count. Moreover, lower PDW was associated with decreased PFS and OS in gastric cancer. Multivariate analysis showed that patients with higher PDW had a lower risk of disease progression (hazard ratio: 0.562, 95% confidence interval: 0.184-0.926, P=0.012) and death (hazard ratio: 0.468, 95% confidence interval: 0.263-0.834, P=0.010).
      Conclusions  Lower preoperative PDW is a poor prognostic factor in gastric cancer, which may also be a prognostic marker in resectable gastric cancer.

     

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