王超, 孙燕. 迁移侵袭抑制蛋白在肿瘤发生发展中的作用及其临床意义[J]. 中国肿瘤临床, 2018, 45(3): 146-151. DOI: 10.3969/j.issn.1000-8179.2018.03.307
引用本文: 王超, 孙燕. 迁移侵袭抑制蛋白在肿瘤发生发展中的作用及其临床意义[J]. 中国肿瘤临床, 2018, 45(3): 146-151. DOI: 10.3969/j.issn.1000-8179.2018.03.307
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Wang Chao, Sun Yan. The role and clinical significance of migration and invasion inhibitory protein in the development and progression of tumors[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(3): 146-151. DOI: 10.3969/j.issn.1000-8179.2018.03.307
Citation: Wang Chao, Sun Yan. The role and clinical significance of migration and invasion inhibitory protein in the development and progression of tumors[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(3): 146-151. DOI: 10.3969/j.issn.1000-8179.2018.03.307
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迁移侵袭抑制蛋白在肿瘤发生发展中的作用及其临床意义

The role and clinical significance of migration and invasion inhibitory protein in the development and progression of tumors

    摘要
  • 摘要: 迁移侵袭抑制蛋白（migration and invasion inhibitory protein，MIIP）能够与胰岛素样生长因子结合蛋白2（insulin-like growth factor binding protein 2，IGFBP2）、组蛋白去乙酰化酶6（histone deacetylase 6，HDAC6）、p21活化激酶1、表皮生长因子受体、细胞分裂周期20（cell division cycle 20，cdc20）、拓扑异构酶等相互作用，抑制细胞增殖和迁移侵袭，进而抑制多种肿瘤的发生发展。最近的研究显示，MIIP还与病毒感染、细胞免疫有关。鉴于MIIP的作用涉及到多条肿瘤相关的信号通路及肿瘤治疗靶点，MIIP逐渐成为研究的热点。本文主要围绕MIIP的分子特征、功能和在多种肿瘤中的临床意义及作用机制进行综述。

     

    Abstract: Migration and invasion inhibitory protein (MIIP) inhibits cell proliferation, migration, and invasion, impeding tumorigenesis and tumor progression, by interacting with insulin-like growth factor binding protein 2 (IGFBP2), histone deacetylase 6 (HDAC6), p21 activated kinase 1 (PAK1), epidermal growth factor receptor (EGFR), cell division cycle 20 (CDC20), and topoisomerase. Recent studies revealed potential roles of MIIP in viral infection and cellular immunity. MIIP has become a research hotspot owing to its involvement in multiple signaling pathways and as a potential therapeutic target for tumors. This review summarizes the characteristics, functions, clinical significance, and possible pathogenic mechanisms of MIIP in multiple carcinomas.

     

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