赵宁, 潘娜, 吴占波, 申学杰, 任红亮, 董一楠, 张姝阳, 魏枫, 张新伟. 非小细胞肺癌组织PD-L1表达的预后意义及其与SUVmax的相关性[J]. 中国肿瘤临床, 2018, 45(4): 167-170. DOI: 10.3969/j.issn.1000-8179.2018.04.040
引用本文: 赵宁, 潘娜, 吴占波, 申学杰, 任红亮, 董一楠, 张姝阳, 魏枫, 张新伟. 非小细胞肺癌组织PD-L1表达的预后意义及其与SUVmax的相关性[J]. 中国肿瘤临床, 2018, 45(4): 167-170. DOI: 10.3969/j.issn.1000-8179.2018.04.040
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Zhao Ning, Pan Na, Wu Zhanbo, Shen Xuejie, Ren Hongliang, Dong Yinan, Zhang Shuyang, Wei Feng, Zhang Xinwei. Prognostic value of PD-L1 expression in non-small cell lung carcinoma and its association with SUVmax[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(4): 167-170. DOI: 10.3969/j.issn.1000-8179.2018.04.040
Citation: Zhao Ning, Pan Na, Wu Zhanbo, Shen Xuejie, Ren Hongliang, Dong Yinan, Zhang Shuyang, Wei Feng, Zhang Xinwei. Prognostic value of PD-L1 expression in non-small cell lung carcinoma and its association with SUVmax[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(4): 167-170. DOI: 10.3969/j.issn.1000-8179.2018.04.040
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非小细胞肺癌组织PD-L1表达的预后意义及其与SUVmax的相关性

Prognostic value of PD-L1 expression in non-small cell lung carcinoma and its association with SUVmax

    摘要
  • 摘要:
      目的  本研究前期探索了程序性死亡配体1（programmed death-ligand 1，PD-L1）在非小细胞肺癌（non-small cell lung carcinoma，NSCLC）组织表达及其与临床因素的关系，发现它与肿瘤分期存在正相关性，进一步分组研究其预后意义及与原发灶最大标准摄取值（maximum standardized uptake value，SUVmax）相关性。
      方法  收集2008年4月至2014年8月122例就诊于天津医科大学肿瘤医院初治原发NSCLC患者的临床影像病理及随访资料，免疫组织化学法检测PD-L1表达情况，采用Kaplan-Meier法及Cox模型进行PD-L1表达的预后分析，Spearman检验分析PD-L1表达与SUVmax的相关性。
      结果  早期NSCLC患者中，PD-L1（HR=4.518，95%CI：1.176-17.352，P=0.028）和肿瘤最大径（HR=1.404，95%CI：1.020-1.933，P=0.037）影响总生存时间（overall survival，OS），是OS的独立预后因子，性别、年龄、病理类型、CEA水平和SUVmax分组对OS差异无统计学意义（P>0.05）；Ⅲ~Ⅳ期NSCLC患者中，性别、病理类型、肿瘤最大径和SUVmax分组是OS的影响因素，年龄、CEA水平、PD-L1表达水平不是OS的影响因素。本研究中，PD-L1表达与SUVmax水平无相关性。
      结论  PD-L1表达是早期NSCLC患者独立预后因子，尚不能成为分期较晚患者的预后因素。PD-L1表达与原发灶SUVmax无相关性。

     

    Abstract:
      Objective   Previous studies have shown an association between programmed death-ligand 1 expression (PD-L1) in nonsmall cell lung cancer (NSCLC) and clinical factors and that PD-L1 is positively correlated with TNM staging. This study aimed to explore the prognostic significance of PD-L1 and its correlation with the maximum standardized uptake value (SUVmax).
      Methods   Clinicopathological data and the follow-up information of the 122 de novo primary NSCLC patients were analyzed. PD-L1 expression was detected by immunohistochemistry in this 122 surgically resected non-small cell lung carcinoma tissues. Survival outcomes were analyzed using the Kaplan-Meier method and multivariate Cox proportional hazards model. Correlation between SUVmax and PD-L1 expression was analyzed using Spearman's rank correlation analysis.
      Results   Multivariate analysis revealed that PD-L1 expression (HR=4.518, 95% CI: 1.176-17.352, P=0.028) and tumor size (HR=1.404, 95%CI: 1.020-1.933, P=0.037) were independent risk factors for overall survival (OS) in early NSCLC patients. Sex, age, pathological type, CEA level, and SUVmax group had no obvious effect on OS (P 0.05) in early NSCLC patients. In univariate analyses, sex, pathological type, tumor size, and SUVmax group affected OS in stage Ⅲ-Ⅳ NSCLC patients. However, age, CEA level, and PD-L1 expression had no effect on OS. PD-L1 expression was not an independent risk factor for OS in stage Ⅲ-Ⅳ NSCLC patients. The SUVmax group had no association with PD-L1 in all patients.
      Conclusions   PD-L1 expression is an independent risk factor for OS in early NSCLC patients but not in stage Ⅲ-Ⅳ patients.

     

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