脑脊液ctDNA检测结果指导治疗肺癌脑转移1例

[1]	Wang Y, Springer S, Zhang M, et al. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord[J]. Proc Natl Acad Sci U S A, 2015, 112(31):9704-9709. doi: 10.1073/pnas.1511694112
[2]	Peng M, Chen C, Hulbert A, et al. Non-blood circulating tumor DNA detection in cancer[J]. Oncotarget, 2017, 8(40):69162-69173.
[3]	De Mattos-Arruda L, Mayor R, Ng CK, et al. Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma[J]. Nat Commun, 2015, 10(6): 8839. https://www.researchgate.net/profile/Francisco_Martinez-Ricarte/publication/283718618_Cerebrospinal_fluid-derived_circulating_tumour_DNA_better_represents_the_genomic_alterations_of_brain_tumours_than_plasma/links/5644bf1f08ae9f9c13e57221.pdf?inViewer=true&pdfJsDownload=true&disableCoverPage=true&origin=publication_detail
[4]	Pan W, Gu W, Nagpal S, et al. Brain tumor mutations detected in cerebral spinal fluid[J]. Clin Chem, 2015, 61(3):514-522. doi: 10.1373/clinchem.2014.235457
[5]	Pentsova EI, Shah RH, Tang J, et al. Evaluating cancer of the central nervous system through next-generation sequencing of cerebrospinal fluid[J]. J Clin Oncol, 2016, 34(20):2404-2415. doi: 10.1200/JCO.2016.66.6487
[6]	Han CH, Brastianos PK. Genetic characterization of brain metastases in the era of targeted therapy[J]. Front Oncol, 2017, 25(7):230.