Abstract:
Objective To review the clinicopathological characteristics and analyze the prognostic factors of hepatoid adenocarcinoma of stomach (HAS).
Methods From August 2012 to June 2017, 30 patients with HAS were diagnosed in Daycare of Peking University Cancer Hospital. Clinicopathological data and follow-up information of these patients were retrospectively collected and analyzed.
Results The median age of these 30 patients was 58 years at diagnosis, with a male-to-female ratio of 2.75:1. Twenty-nine patients were confirmed to have lymph node metastases and 7 patients had distant metastases. Ten patients died because of the cancer within the follow-up period. The 1-and 3-year survival rates were 60% and 52%, respectively. Cox multivariate regression revealed that elevated serum CA199 levels, higher lymph node staging, not having undergone radical surgery, and stronger immunohistochemical (IHC) staining intensity of alpha fetoprotein (AFP) were independent poor prognostic factors.
Conclusions Elevated serum CA199 levels, lymph node staging, and IHC staining intensity of AFP are verified in this study as independent risk factors of poor outcome in HAS patients. Early detection and diagnosis of the disease may improve the clinical prognosis. Multidisciplinary team discussions are important in making therapy decisions and radical surgery should be performed whenever possible.
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