Abstract: The increase of fatty acid synthesis is the third biggest metabolic phenotype of tumor cells, and sterol regulatory element binding transcription factor 1 (SREBP1) is the major nuclear transcription factor involved in lipid metabolism, especially in the synthesis of fatty acid. The expression of SREBP1 is elevated in multiple tumors, which plays an important role in tumor proliferation, apoptosis, invision, drug resistance, energy metabolism etc. In this paper, we will review the research progress on SREBP1 in tumor.