Abstract: Epithelial-to-mesenchymal transition (EMT) is a normal process of cell physiological development in which the epithelialcells transform into mesenchymal cells through a specific program. EMT plays key roles in embryogenesis, tissue regeneration, and tumor progression. Recent research has shown the involvement of EMT-like in the tumorigenesis and progression (especially invasionand metastasis) of glioblastoma (GBM). This article reviews the molecular regulatory mechanisms of EMT (-like) including the main signaling pathways, EMT-factors, miRNA, cancer stem cells, hypoxia microenvironments, and therapy resistance in GBM.