Abstract: New developments in radiomics and bio-omics, blockchain, digital twins, cloud-to-edge computing, big data, and artificialintelligence are revolutionizing cancer radiotherapy, with breakthroughs in treatment accuracy and efficacy. Smart omics-guided radiotherapy will eventually resolve the problem of radiotherapy. In the radiotherapy decision-making, the whole genetic information andbiological characteristics of tumors and individuals can be obtained through the methods of omics technology. For the determinationof radiotherapy targets, through the image technique it provides the full genetics and microenvironmental information of the cancerlesion. For treatment response evaluation and follow-up, it can timely optimize the radiotherapy plan and monitor the tumor by realtime dynamic observation of changes in various histological information throughout the treatment process. The advantages of thetreatment model are reflected in accurate decision-making, avoiding "blind people's touch" and partial errors. Holographic target identification avoids the uncertainty caused by manual delineation of targets, and full and dynamic histological evaluation can promote theearly detection of tumor recurrence.