FLOT-1在人类实体肿瘤中的研究进展

摘要: 浮舰蛋白-1（flotillin-1，FLOT-1）属于脂筏标记蛋白，参与多种细胞生理活动，与许多肿瘤发生发展密切相关。FLOT-1在乳腺癌、食管鳞状癌、肾细胞癌（renal cell carcinoma，RCC）、移行细胞癌（transitional cell carcinoma，TCC）、非小细胞肺癌（nonsmall cell lung cancer，NSCLC）、肝细胞癌等肿瘤中均高表达，并与临床分期、转移、浸润和预后相关。本文综述了FLOT-1的结构和功能，及其在多种人类实体肿瘤中的作用。
- FLOT-1 /
- 脂筏 /
- 肿瘤
Abstract: Flotillin-1 (FLOT-1) is one of the protein markers of lipid rafts. It is involved in a variety of cell physiological activities and is also closely related to the development of many tumors. Recent research reports indicate that FLOT-1 is highly expressed in breast cancer, esophageal squamous cell carcinoma, renal cell carcinoma, bladder cancer, non-small cell lung cancer, and hepatocellular carcinoma, and it is associated with clinical grade, transfer, infiltration, and prognosis. This study briefly summarizes the structure and function of FLOT-1 and its role in a wide variety of human solid tumors.
- FLOT-1 /
- lipid rafts /
- tumor

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参考文献(36)

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