Abstract: Objective: To evaluate the short-term efficacy and the long-term quality of life after surgery using different mechanical sta-plers in Billroth II reconstruction after distal gastrectomy for gastric cancer. Methods: The clinical data of patients with gastric adeno-carcinoma who received distal gastrectomies with Billroth Ⅱ reconstruction in the Department of Gastrointestinal Surgery Ward Ⅳ of Peking University Cancer Hospital, from January 2013 to July 2017, were collected retrospectively. A total of 132 patients were en-rolled in the study, with 64 patients in the CS (circular stapler) group and 68 patients in the LS (linear stapler) group. The clinicopatho-logic characteristics, operative features, postoperative recovery, complication rate, and endoscopy scan for remnant stomach at 1 year after operation were compared between these two groups. Results: There was no significant difference between the two groups in op-eration time, operation approach, intraoperative bleeding, number of lymph node dissections, and number of positive lymph nodes (all P > 0.05). On postoperative recovery, the first flatus time (3.0 days vs. 4.0 days), first liquid diet time (7.0 days vs. 8.0 days), first ab-dominal drainage tube removing time (7.0 days vs. 9.0 days), and postoperative hospital stay (8.0 days vs. 10.0 days) were shorter in the LS group than in the CS group (all P < 0.05). The rates of postoperative complications were 10.9% and 1.5% in the CS and LS groups, respectively (P=0.056), withnot significant difference. The endoscopies revealed that there were no significant differences in residual food, gastritis, and bile reflux at 12 months postoperatively. Conclusions: For distal gastrectomies with Billroth Ⅱ reconstruction, gas-trointestinal function recovery was faster and postoperative hospital stay was shorter in the LS group than in the CS group.