徐世斌, 徐美青, 孙效辉, 邓杰, 吴汉然, 熊燃, 解明然. 预后营养指数与食管鳞癌患者术后并发症和远期预后的相关性研究[J]. 中国肿瘤临床, 2018, 45(15): 789-794. DOI: 10.3969/j.issn.1000-8179.2018.15.451
引用本文: 徐世斌, 徐美青, 孙效辉, 邓杰, 吴汉然, 熊燃, 解明然. 预后营养指数与食管鳞癌患者术后并发症和远期预后的相关性研究[J]. 中国肿瘤临床, 2018, 45(15): 789-794. DOI: 10.3969/j.issn.1000-8179.2018.15.451
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Xu Shibin, Xu Meiqing, Sun Xiaohui, Deng Jie, Wu Hanran, Xiong Ran, Xie Mingran. The correlation of prognostic nutritional index with postoperative complications and prognosis in patients with esophageal cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(15): 789-794. DOI: 10.3969/j.issn.1000-8179.2018.15.451
Citation: Xu Shibin, Xu Meiqing, Sun Xiaohui, Deng Jie, Wu Hanran, Xiong Ran, Xie Mingran. The correlation of prognostic nutritional index with postoperative complications and prognosis in patients with esophageal cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(15): 789-794. DOI: 10.3969/j.issn.1000-8179.2018.15.451
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预后营养指数与食管鳞癌患者术后并发症和远期预后的相关性研究

The correlation of prognostic nutritional index with postoperative complications and prognosis in patients with esophageal cancer

    摘要
  • 摘要:
      目的  分析预后营养指数（prognostic nutritional index，PNI）和食管鳞癌患者术后并发症与预后的关系。
      方法  回顾性分析2010年1月至2011年12月中国科学技术大学附属第一医院收治的食管鳞癌术后患者258例。其中高PNI患者157例，低PNI患者101例。比较两组患者临床病理特征、术后并发症、中位生存期和5年生存率。
      结果  低PNI组患者的TNM分期较晚，肿瘤直径 > 3 cm、有吸烟史、饮酒史和血清白蛋白值低的患者较多（P < 0.05）。高PNI组总并发症（28.0% vs. 40.6%）、肺部并发症（7.6% vs. 16.8%）和吻合口瘘发生率（4.5% vs. 40.9%）低于低PNI组（P < 0.05）。高PNI组中位生存期和第1、3和5年生存率均优于低PNI组（87.3%，71.3%，50.3% vs. 76.2%，56.4%，32.7%，P < 0.001）。Cox多因素生存分析显示TNM分期和PNI水平与生存率显著相关（P < 0.05）。
      结论  术前PNI可用于判断食管癌术后患者预后状况。

     

    Abstract:
      Objective  To investigate the correlation between the prognostic nutritional index (PNI) and postoperative complications or survival rates in patients with esophageal cancer who have undergone surgery.
      Methods  This study retrospectively reviewed and analyzed 258 patients who were pathologically diagnosed with esophageal cancer and underwent surgery between January 2010 and December 2011 in the First Affiliated Hospital of University of Science and Technology of China. Among them, 157 patients were in the high (H)-PNI group, and 101 patients were in the low (L)-PNI group. The clinicopathologic features, postoperative complication rates, median survival time, and 5- year survival rates in the two groups were analyzed.
      Results  Patients in the L- PNI group had greater pathologic tumor-node-metastasis (TNM) stage, larger tumors, lower serum albumin levels, greater percentage of smoking habits, and a history of alcohol consumption compared with patients in the H-PNI group (P < 0.05). The H-PNI group was associated with significantly fewer postoperative complications compared with the L-PNI group (P < 0.05). The H-PNI group was associated with significantly longer median survival time (MST) and 1-, 3-, and 5-year overall survival (53.3 month, 87.3%, 71.3%, 50.3%) compared with the L-PNI group (41.5 month, 76.2%, 56.4%, 32.7%)(P < 0.001). The multivariate analyses showed that TNM staging and PNI status were independent factors in predicting survival rates.
      Conclusions  The preoperative PNI can be a potential predictor for the prognosis of patients with esophageal cancer after surgery.

     

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