郑又文, 马永琛, 陈善稳, 朱静, 于妍斐, 王鹏远, 杨兴, 陈国卫. 90例结直肠癌中前列腺特异性膜抗原的表达研究[J]. 中国肿瘤临床, 2018, 45(16): 827-831. DOI: 10.3969/j.issn.1000-8179.2018.16.555
引用本文: 郑又文, 马永琛, 陈善稳, 朱静, 于妍斐, 王鹏远, 杨兴, 陈国卫. 90例结直肠癌中前列腺特异性膜抗原的表达研究[J]. 中国肿瘤临床, 2018, 45(16): 827-831. DOI: 10.3969/j.issn.1000-8179.2018.16.555
shu
Zheng Youwen, Ma Yongchen, Chen Shanwen, Zhu Jing, Yu Yanfei, Wang Pengyuan, Yang Xing, Chen Guowei. Expression of prostate-specific membrane antigen in 90 colorectal cancer patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(16): 827-831. DOI: 10.3969/j.issn.1000-8179.2018.16.555
Citation: Zheng Youwen, Ma Yongchen, Chen Shanwen, Zhu Jing, Yu Yanfei, Wang Pengyuan, Yang Xing, Chen Guowei. Expression of prostate-specific membrane antigen in 90 colorectal cancer patients[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2018, 45(16): 827-831. DOI: 10.3969/j.issn.1000-8179.2018.16.555
shu

90例结直肠癌中前列腺特异性膜抗原的表达研究

Expression of prostate-specific membrane antigen in 90 colorectal cancer patients

    摘要
  • 摘要:
      目的  探讨结直肠癌（colorectal cancer，CRC）患者中前列腺特异性膜抗原（prostate-specific membrane antigen，PSMA）的表达及临床病理影响因素。
      方法  选取90例CRC患者的组织切片，应用免疫组织化学检测癌组织和癌旁正常组织的PSMA、血管标志蛋白CD31的表达水平，并对PSMA的表达水平与CRC临床病理因素的关系进行分析。
      结果  PSMA在正常结直肠组织中免疫组织化学染色为阴性，在CRC组织中有较高比例免疫组织化学染色。但染色阳性部位不在肿瘤细胞，而是在肿瘤新生血管内皮细胞，总染色率为76.7%。PSMA染色评分在不同年龄及组织学类型中具有显著性差异，高年龄组（≥60岁）及普通型腺癌组的PSMA染色评分更高（P < 0.05）。
      结论  PSMA在90例CRC患者中高比例表达，表达部位为肿瘤新生血管内皮细胞，与部分临床病理因素有关，可能成为CRC诊断及治疗的特异性标志物。

     

    Abstract:
      Objective  To explore the expression of prostate-specific membrane antigen (PSMA) and its correlation with the clinicopathological parameters of colorectal cancer (CRC) patients.
      Methods  Immunohistochemistry was used to examine the expression of PSMA in colorectal cancer and adjacent normal tissues obtained from 90 patients from Alenabio company, Xi'an, China. CD31 staining was also performed as a reference. The correlation between PSMA expression and clinicopathological parameters was analyzed.
      Results  The expression of PSMA was absent in the adjacent normal colorectal tissues. However, a high PSMA staining rate (76.7%) was observed in colorectal cancer tissues. Moreover, PSMA staining was not observed in cancer cells, but in tumor-associated neo-vasculature. The statistical analysis showed that the PSMA staining scores were significantly different based on the age and histological type. The PSMA staining scores in the elderly group (≥60 years old) and the common adenocarcinoma group were higher (P < 0.05).
      Conclusions  The percentage of PSMA-positive colorectal cancer cells in the 90 CRC patients was high and PSMA was mainly expressed in the endothelial cells of tumor-associated neo-vasculature. Thus, PSMA could be a potential biomarker for the diagnosis and treatment of colorectal cancer.

     

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